Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels

SCF ubiquitin ligases target numerous proteins for ubiquitin dependent proteolysis, including p27 and cyclin E. SCF and other cullin-RING ligases (CRLs) are regulated by the ubiquitin-like protein Nedd8 that covalently modifies the cullin subunit. The removal of Nedd8 is catalyzed by the Jab1/MPN do...

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Veröffentlicht in:	BMC biochemistry 2006-01, Vol.7 (1), p.1-1, Article 1
Hauptverfasser:	Cope, Gregory A, Deshaies, Raymond J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line COP9 Signalosome Complex Down-Regulation - genetics F-Box Proteins - antagonists & inhibitors F-Box Proteins - genetics F-Box Proteins - metabolism Gene Silencing - physiology Gene Targeting - methods Humans Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - physiology Peptide Hydrolases - deficiency Peptide Hydrolases - genetics Peptide Hydrolases - physiology SKP Cullin F-Box Protein Ligases - genetics SKP Cullin F-Box Protein Ligases - metabolism
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