Detection of hepatic metastases using duplex/color Doppler sonography
Current imaging modalities are unable to detect small liver metastases because of limited resolution and contrast differentiation. The association between liver metastases and altered liver blood flow has been demonstrated by dynamic scintigraphy, but the clinical feasibility of this test has been q...
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| Veröffentlicht in: | Annals of surgery 1991-11, Vol.214 (5), p.599-604 |
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| container_title | Annals of surgery |
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| creator | LEEN, E GOLDBERG, J. A ROBERTSON, J ROY SUTHERLAND, G HEMINGWAY, D. M COOKE, T. G MCARDLE, C. S |
| description | Current imaging modalities are unable to detect small liver metastases because of limited resolution and contrast differentiation. The association between liver metastases and altered liver blood flow has been demonstrated by dynamic scintigraphy, but the clinical feasibility of this test has been questioned. In this study a novel approach to detecting liver metastases was assessed by measurement of liver blood flow using a duplex/color Doppler System. Hepatic arterial and portal venous blood flows were measured in 16 controls, 50 patients with gastrointestinal cancer, and 6 patients with breast cancer. The ratio of hepatic arterial to total liver blood flow (Doppler perfusion index, DPI) and the ratio of hepatic arterial: portal venous blood flow (Doppler flow ratio, DFR) were calculated. The DPI and DFR values of controls and patients with overt liver metastases were clearly separated (p less than 0.0001). The results suggest that duplex/color Doppler ultrasound measurement of hepatic perfusion changes may be of value in the detection of liver metastases. |
| doi_str_mv | 10.1097/00000658-199111000-00010 |
| format | Article |
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The ratio of hepatic arterial to total liver blood flow (Doppler perfusion index, DPI) and the ratio of hepatic arterial: portal venous blood flow (Doppler flow ratio, DFR) were calculated. The DPI and DFR values of controls and patients with overt liver metastases were clearly separated (p less than 0.0001). The results suggest that duplex/color Doppler ultrasound measurement of hepatic perfusion changes may be of value in the detection of liver metastases.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/00000658-199111000-00010</identifier><identifier>PMID: 1953113</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Flow Velocity ; Breast Neoplasms - pathology ; Colorectal Neoplasms - pathology ; Digestive system. Abdomen ; Hepatic Artery - diagnostic imaging ; Hepatic Artery - physiopathology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Liver Neoplasms - blood supply ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - secondary ; Medical sciences ; Middle Aged ; Portal Vein - diagnostic imaging ; Portal Vein - physiopathology ; Ultrasonic investigative techniques ; Ultrasonography</subject><ispartof>Annals of surgery, 1991-11, Vol.214 (5), p.599-604</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-f290499813a13074d11810dc8a4f9901ca31c591a235f29ea05f5c5ec3ae62443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1358616/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1358616/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5504441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1953113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEEN, E</creatorcontrib><creatorcontrib>GOLDBERG, J. 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Hepatic arterial and portal venous blood flows were measured in 16 controls, 50 patients with gastrointestinal cancer, and 6 patients with breast cancer. The ratio of hepatic arterial to total liver blood flow (Doppler perfusion index, DPI) and the ratio of hepatic arterial: portal venous blood flow (Doppler flow ratio, DFR) were calculated. The DPI and DFR values of controls and patients with overt liver metastases were clearly separated (p less than 0.0001). The results suggest that duplex/color Doppler ultrasound measurement of hepatic perfusion changes may be of value in the detection of liver metastases.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Breast Neoplasms - pathology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Digestive system. Abdomen</subject><subject>Hepatic Artery - diagnostic imaging</subject><subject>Hepatic Artery - physiopathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver Neoplasms - blood supply</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - secondary</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Portal Vein - diagnostic imaging</subject><subject>Portal Vein - physiopathology</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1PwzAMjRBojMFPQOoBcSuLm6RtLkhoGx8SEhc4RyZNt6K2KUmL2L8nY2NA5Miy3_NzlEdIBPQKqMymdHNSkccgJQCEIg4X6AEZg0hCGzg9JOPQYzGXLDkmJ96_BQbPaTYiI5CCAbAxWcxNb3Rf2TayZbQyHfaVjhrTow9hfDT4ql1GxdDV5nOqbW1dNLddqFzkbWuXDrvV-pQclVh7c7bLE_Jyu3ie3cePT3cPs5vHWAugfVwmknIpc2AIjGa8AMiBFjpHXkpJQSMDLSRgwkTgGqSiFFoYzdCkCedsQq63ut3w2phCm7Z3WKvOVQ26tbJYqf9IW63U0n4oYCJPIQ0ClzsBZ98H43vVVF6busbW2MGrLOFSCGCBmG-J2lnvnSn3S4CqjQXqxwK1t0B9WxBGz_8-8ndw--cBv9jh6DXWpcNWV35PE4JyzoF9AZSRjso</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>LEEN, E</creator><creator>GOLDBERG, J. 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Abdomen</topic><topic>Hepatic Artery - diagnostic imaging</topic><topic>Hepatic Artery - physiopathology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver Neoplasms - blood supply</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - secondary</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Portal Vein - diagnostic imaging</topic><topic>Portal Vein - physiopathology</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEEN, E</creatorcontrib><creatorcontrib>GOLDBERG, J. A</creatorcontrib><creatorcontrib>ROBERTSON, J</creatorcontrib><creatorcontrib>ROY SUTHERLAND, G</creatorcontrib><creatorcontrib>HEMINGWAY, D. M</creatorcontrib><creatorcontrib>COOKE, T. G</creatorcontrib><creatorcontrib>MCARDLE, C. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Journals@Ovid Complete |
| subjects | Adult Aged Biological and medical sciences Blood Flow Velocity Breast Neoplasms - pathology Colorectal Neoplasms - pathology Digestive system. Abdomen Hepatic Artery - diagnostic imaging Hepatic Artery - physiopathology Humans Investigative techniques, diagnostic techniques (general aspects) Liver Neoplasms - blood supply Liver Neoplasms - diagnostic imaging Liver Neoplasms - secondary Medical sciences Middle Aged Portal Vein - diagnostic imaging Portal Vein - physiopathology Ultrasonic investigative techniques Ultrasonography |
| title | Detection of hepatic metastases using duplex/color Doppler sonography |
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