Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog
The efficacy of lovastatin, an inhibitor of hepatic cholesterol synthesis in the prevention of cholesterol gallstone formation, was evaluated in the prairie dog model. Two groups of animals were maintained on either nonlithogenic or 1.2% cholesterol-enriched chow for 21 days. Seven of the animals in...
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| Veröffentlicht in: | Annals of surgery 1991-08, Vol.214 (2), p.149-154 |
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| container_title | Annals of surgery |
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| creator | SAUNDERS, K. D CATES, J. A ABEDIN, M. Z REGE, S FESTEKDJIAN, S. F HOWARD, W ROSLYN, J. J |
| description | The efficacy of lovastatin, an inhibitor of hepatic cholesterol synthesis in the prevention of cholesterol gallstone formation, was evaluated in the prairie dog model. Two groups of animals were maintained on either nonlithogenic or 1.2% cholesterol-enriched chow for 21 days. Seven of the animals in each group received lovastatin, and the remaining six received only distilled water. All of the cholesterol-fed/water-treated animals had crystals and 83% had gallstones, but none of the cholesterol-fed/lovastatin-treated animals had gallstones and only three had microscopic crystals. These data indicate that lovastatin inhibits cholesterol gallstone formation in a diet-induced model of gallstone disease. |
| doi_str_mv | 10.1097/00000658-199108000-00009 |
| format | Article |
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These data indicate that lovastatin inhibits cholesterol gallstone formation in a diet-induced model of gallstone disease.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/00000658-199108000-00009</identifier><identifier>PMID: 1867522</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Animals ; Bile - metabolism ; Biological and medical sciences ; Cholelithiasis - chemically induced ; Cholelithiasis - chemistry ; Cholelithiasis - prevention & control ; Cholesterol - analysis ; Cholesterol, Dietary - adverse effects ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Gallbladder - metabolism ; General and cellular metabolism. Vitamins ; Liver - metabolism ; Lovastatin - pharmacology ; Male ; Medical sciences ; Pharmacology. 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All of the cholesterol-fed/water-treated animals had crystals and 83% had gallstones, but none of the cholesterol-fed/lovastatin-treated animals had gallstones and only three had microscopic crystals. These data indicate that lovastatin inhibits cholesterol gallstone formation in a diet-induced model of gallstone disease.</description><subject>Animals</subject><subject>Bile - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cholelithiasis - chemically induced</subject><subject>Cholelithiasis - chemistry</subject><subject>Cholelithiasis - prevention & control</subject><subject>Cholesterol - analysis</subject><subject>Cholesterol, Dietary - adverse effects</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Gallbladder - metabolism</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Liver - metabolism</subject><subject>Lovastatin - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Sciuridae</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1OAyEUhYnR1Fp9BBMWbkdhgBnYmJjG3zRxo2sCDLSY6dAAmvj2MrZWZXEJ37nnkBwAIEaXGIn2Co2nYbzCQmDEy6MaiTgAU8zqgjFFh2BaEKmoIPUxOEnpDSFMOWonYIJ507K6noKnRfhQKavsB-iHldc-J7hUfZ9yGCx0Ia6LFkYR5pWFZhV6m7KNoa-c7eAmKh-9hV1YnoIjp_pkz3b3DLze3b7MH6rF8_3j_GZRGUpprkTTUSu0s7SptSnTGKtaxLTQgpCuUc7WrOWmoQpzRjCtu0IUcVoIrgkjM3C9zd2867XtjB1yVL3cRL9W8VMG5eV_ZfAruQwfEhPGGaYlgG8DTAwpRev2XozkWK_8qVfu6_1GoljP__79a9z2WfSLna6SUb2LajA-7dcY4QgjRr4AtFOE4Q</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>SAUNDERS, K. D</creator><creator>CATES, J. 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| ispartof | Annals of surgery, 1991-08, Vol.214 (2), p.149-154 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; PubMed Central |
| subjects | Animals Bile - metabolism Biological and medical sciences Cholelithiasis - chemically induced Cholelithiasis - chemistry Cholelithiasis - prevention & control Cholesterol - analysis Cholesterol, Dietary - adverse effects Cholesterol, HDL - blood Cholesterol, LDL - blood Gallbladder - metabolism General and cellular metabolism. Vitamins Liver - metabolism Lovastatin - pharmacology Male Medical sciences Pharmacology. Drug treatments Sciuridae |
| title | Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog |
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