Increase of survival benefit in advanced resectable colon cancer by extent of adjuvant treatment : Results of a randomized trial comparing modulation of 5-FU + Levamisole with folinic acid or with interferon-α

The benefit of adjuvant therapy in curatively resected lymph node-positive colon cancer was established using 5-fluorouracil (5-FU) and levamisole (LEV) for 12 months. 5-FU cytotoxicity can be modulated by folinic acid (FA) or interferon-alpha (INF-alpha). The aim of this study was to investigate th...

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Veröffentlicht in:	Annals of surgery 2005-08, Vol.242 (2), p.178-187
Hauptverfasser:	LINK, Karl-Heinz, KORNMANN, Marko, STAIB, Ludger, REDENBACHER, Martin, KRON, Martina, BEGER, Hans Gunter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - toxicity Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antineoplastic Combined Chemotherapy Protocols - toxicity Biological and medical sciences Chemotherapy, Adjuvant Colonic Neoplasms - mortality Colonic Neoplasms - therapy Female Fluorouracil - administration & dosage Fluorouracil - toxicity Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Interferon-alpha - administration & dosage Leucovorin - administration & dosage Levamisole - administration & dosage Male Medical sciences Middle Aged Patient Compliance Randomized, Controlled Trials Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Tumors
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