Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

Pdx1 (IPF-1 in humans, which is altered in MODY-4) is essential for pancreas development and mature beta-cell function. Pdx1 is expressed dynamically within the developing foregut, but how its expression characteristics are linked to the various steps of organ specification, differentiation, and fun...

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Veröffentlicht in:	Genes & development 2006-01, Vol.20 (2), p.253-266
Hauptverfasser:	Fujitani, Yoshio, Fujitani, Shuko, Boyer, Daniel F, Gannon, Maureen, Kawaguchi, Yoshiya, Ray, Michael, Shiota, Masakazu, Stein, Roland W, Magnuson, Mark A, Wright, Christopher V E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Conserved Sequence Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Enteroendocrine Cells - metabolism Female Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Intestines - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Mutation Organogenesis - genetics Pancreas - embryology Pancreas - metabolism Regulatory Sequences, Nucleic Acid - genetics Regulatory Sequences, Nucleic Acid - physiology Research Papers Trans-Activators - genetics Trans-Activators - metabolism
Online-Zugang:	Volltext
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