Extension of chronological life span in yeast by decreased TOR pathway signaling

Chronological life span (CLS) in Saccharomyces cerevisiae, defined as the time cells in a stationary phase culture remain viable, has been proposed as a model for the aging of post-mitotic tissues in mammals. We developed a high-throughput assay to determine CLS for approximately 4800 single-gene de...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes & development 2006-01, Vol.20 (2), p.174-184
Hauptverfasser:	Powers, 3rd, R Wilson, Kaeberlein, Matt, Caldwell, Seth D, Kennedy, Brian K, Fields, Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Conserved Sequence DNA-Binding Proteins - metabolism Gene Deletion Gene Expression Regulation, Fungal Hot Temperature Longevity Mutation Nuclear Localization Signals - metabolism Oxidative Stress - genetics Oxidative Stress - physiology Phenotype Protein-Serine-Threonine Kinases Repressor Proteins - genetics Research Papers Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Homology Signal Transduction - genetics Signal Transduction - physiology Transcription Factors - genetics Transcription Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!