Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA damage is poorly understood. Following exposure to genotoxic stress, DNA damage-specific interactions wer...
Gespeichert in:
| Veröffentlicht in: | Genes & development 2006-01, Vol.20 (1), p.34-46 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 46 |
|---|---|
| container_issue | 1 |
| container_start_page | 34 |
| container_title | Genes & development |
| container_volume | 20 |
| creator | Greenberg, Roger A Sobhian, Bijan Pathania, Shailja Cantor, Sharon B Nakatani, Yoshihiro Livingston, David M |
| description | The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA damage is poorly understood. Following exposure to genotoxic stress, DNA damage-specific interactions were observed between BRCA1/BARD1 and the DNA damage-response proteins, TopBP1 and Mre11/Rad50/NBS1. Two distinct DNA damage-dependent super complexes emerged; their activation was dependent, in part, on the actions of specific checkpoint kinases, and each super complex contributed to a distinctive aspect of the DNA damage response. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions. |
| doi_str_mv | 10.1101/gad.1381306 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1356099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67604933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-269a71bd08975ab2044f39f5586206ce49a10e19d9d00729f4bd0f878068ebc3</originalsourceid><addsrcrecordid>eNqFkb1P5DAUxC10CPaAiv7k6hoUeC927LhBWhbuQOJDQvTGcZzFpyRe4uQE_z1GrPioqF4xvzea0RCyj3CICHi0NPUhshIZiA0yw4KrrOBS_iAzKBVkigm1TX7G-A8ABAixRbZRMIU5wxm5v5ra0TfGjmHwpqU29OPgq2n0oY90DNT01NhpdPT0ek5r05mlo4OLqyQ7Wj3Tk9vFHI9O5renmL0-G9_7fpl8ulXrnlzcJZuNaaPbW98dcvfn7G5xnl3e_L1YzC8zy6UYs1woI7GqU2RZmCoHzhummqIoRQ7COq4MgkNVqxpA5qrhiW1KWYIoXWXZDjl-s11NVedq61IN0-rV4DszPOtgvP6q9P5BL8N_jawQoFQy-L02GMLj5OKoOx-ta1vTuzBFLaQArhj7FkTJSykYJvDgDbRDiHFwzXsaBP26nE7L6fVyif71ucAHu56KvQC2rJRD</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17487631</pqid></control><display><type>article</type><title>Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Greenberg, Roger A ; Sobhian, Bijan ; Pathania, Shailja ; Cantor, Sharon B ; Nakatani, Yoshihiro ; Livingston, David M</creator><creatorcontrib>Greenberg, Roger A ; Sobhian, Bijan ; Pathania, Shailja ; Cantor, Sharon B ; Nakatani, Yoshihiro ; Livingston, David M</creatorcontrib><description>The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA damage is poorly understood. Following exposure to genotoxic stress, DNA damage-specific interactions were observed between BRCA1/BARD1 and the DNA damage-response proteins, TopBP1 and Mre11/Rad50/NBS1. Two distinct DNA damage-dependent super complexes emerged; their activation was dependent, in part, on the actions of specific checkpoint kinases, and each super complex contributed to a distinctive aspect of the DNA damage response. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.</description><identifier>ISSN: 0890-9369</identifier><identifier>EISSN: 1549-5477</identifier><identifier>DOI: 10.1101/gad.1381306</identifier><identifier>PMID: 16391231</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Acid Anhydride Hydrolases ; BRCA1 Protein - genetics ; BRCA1 Protein - metabolism ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell Cycle ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell Line, Tumor ; DNA Damage ; DNA Repair ; DNA Repair Enzymes - genetics ; DNA Repair Enzymes - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Humans ; MRE11 Homologue Protein ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Protein Binding ; Research Papers ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - metabolism ; Ubiquitin-Protein Ligases - genetics ; Ubiquitin-Protein Ligases - metabolism</subject><ispartof>Genes & development, 2006-01, Vol.20 (1), p.34-46</ispartof><rights>Copyright © 2006, Cold Spring Harbor Laboratory Press 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-269a71bd08975ab2044f39f5586206ce49a10e19d9d00729f4bd0f878068ebc3</citedby><cites>FETCH-LOGICAL-c476t-269a71bd08975ab2044f39f5586206ce49a10e19d9d00729f4bd0f878068ebc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356099/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356099/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16391231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenberg, Roger A</creatorcontrib><creatorcontrib>Sobhian, Bijan</creatorcontrib><creatorcontrib>Pathania, Shailja</creatorcontrib><creatorcontrib>Cantor, Sharon B</creatorcontrib><creatorcontrib>Nakatani, Yoshihiro</creatorcontrib><creatorcontrib>Livingston, David M</creatorcontrib><title>Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes</title><title>Genes & development</title><addtitle>Genes Dev</addtitle><description>The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA damage is poorly understood. Following exposure to genotoxic stress, DNA damage-specific interactions were observed between BRCA1/BARD1 and the DNA damage-response proteins, TopBP1 and Mre11/Rad50/NBS1. Two distinct DNA damage-dependent super complexes emerged; their activation was dependent, in part, on the actions of specific checkpoint kinases, and each super complex contributed to a distinctive aspect of the DNA damage response. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.</description><subject>Acid Anhydride Hydrolases</subject><subject>BRCA1 Protein - genetics</subject><subject>BRCA1 Protein - metabolism</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Cycle</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line, Tumor</subject><subject>DNA Damage</subject><subject>DNA Repair</subject><subject>DNA Repair Enzymes - genetics</subject><subject>DNA Repair Enzymes - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>MRE11 Homologue Protein</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Protein Binding</subject><subject>Research Papers</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tumor Suppressor Proteins - metabolism</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><subject>Ubiquitin-Protein Ligases - metabolism</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1P5DAUxC10CPaAiv7k6hoUeC927LhBWhbuQOJDQvTGcZzFpyRe4uQE_z1GrPioqF4xvzea0RCyj3CICHi0NPUhshIZiA0yw4KrrOBS_iAzKBVkigm1TX7G-A8ABAixRbZRMIU5wxm5v5ra0TfGjmHwpqU29OPgq2n0oY90DNT01NhpdPT0ek5r05mlo4OLqyQ7Wj3Tk9vFHI9O5renmL0-G9_7fpl8ulXrnlzcJZuNaaPbW98dcvfn7G5xnl3e_L1YzC8zy6UYs1woI7GqU2RZmCoHzhummqIoRQ7COq4MgkNVqxpA5qrhiW1KWYIoXWXZDjl-s11NVedq61IN0-rV4DszPOtgvP6q9P5BL8N_jawQoFQy-L02GMLj5OKoOx-ta1vTuzBFLaQArhj7FkTJSykYJvDgDbRDiHFwzXsaBP26nE7L6fVyif71ucAHu56KvQC2rJRD</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Greenberg, Roger A</creator><creator>Sobhian, Bijan</creator><creator>Pathania, Shailja</creator><creator>Cantor, Sharon B</creator><creator>Nakatani, Yoshihiro</creator><creator>Livingston, David M</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060101</creationdate><title>Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes</title><author>Greenberg, Roger A ; Sobhian, Bijan ; Pathania, Shailja ; Cantor, Sharon B ; Nakatani, Yoshihiro ; Livingston, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-269a71bd08975ab2044f39f5586206ce49a10e19d9d00729f4bd0f878068ebc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acid Anhydride Hydrolases</topic><topic>BRCA1 Protein - genetics</topic><topic>BRCA1 Protein - metabolism</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell Cycle</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line, Tumor</topic><topic>DNA Damage</topic><topic>DNA Repair</topic><topic>DNA Repair Enzymes - genetics</topic><topic>DNA Repair Enzymes - metabolism</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>MRE11 Homologue Protein</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Protein Binding</topic><topic>Research Papers</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Tumor Suppressor Proteins - metabolism</topic><topic>Ubiquitin-Protein Ligases - genetics</topic><topic>Ubiquitin-Protein Ligases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenberg, Roger A</creatorcontrib><creatorcontrib>Sobhian, Bijan</creatorcontrib><creatorcontrib>Pathania, Shailja</creatorcontrib><creatorcontrib>Cantor, Sharon B</creatorcontrib><creatorcontrib>Nakatani, Yoshihiro</creatorcontrib><creatorcontrib>Livingston, David M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenberg, Roger A</au><au>Sobhian, Bijan</au><au>Pathania, Shailja</au><au>Cantor, Sharon B</au><au>Nakatani, Yoshihiro</au><au>Livingston, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>20</volume><issue>1</issue><spage>34</spage><epage>46</epage><pages>34-46</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><abstract>The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA damage is poorly understood. Following exposure to genotoxic stress, DNA damage-specific interactions were observed between BRCA1/BARD1 and the DNA damage-response proteins, TopBP1 and Mre11/Rad50/NBS1. Two distinct DNA damage-dependent super complexes emerged; their activation was dependent, in part, on the actions of specific checkpoint kinases, and each super complex contributed to a distinctive aspect of the DNA damage response. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>16391231</pmid><doi>10.1101/gad.1381306</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-9369 |
| ispartof | Genes & development, 2006-01, Vol.20 (1), p.34-46 |
| issn | 0890-9369 1549-5477 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1356099 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Acid Anhydride Hydrolases BRCA1 Protein - genetics BRCA1 Protein - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor DNA Damage DNA Repair DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans MRE11 Homologue Protein Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Research Papers Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism |
| title | Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T00%3A26%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multifactorial%20contributions%20to%20an%20acute%20DNA%20damage%20response%20by%20BRCA1/BARD1-containing%20complexes&rft.jtitle=Genes%20&%20development&rft.au=Greenberg,%20Roger%20A&rft.date=2006-01-01&rft.volume=20&rft.issue=1&rft.spage=34&rft.epage=46&rft.pages=34-46&rft.issn=0890-9369&rft.eissn=1549-5477&rft_id=info:doi/10.1101/gad.1381306&rft_dat=%3Cproquest_pubme%3E67604933%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17487631&rft_id=info:pmid/16391231&rfr_iscdi=true |