secretion of pepsin
1. Ligation and division of the vessels supplying the stomach, except those from the spleen, result in greatly increased pepsin secretion in response to pentagastrin, pilocarpine or 2-deoxy-D-glucose. 2. This effect was still present 6 months after initial ligation. 3. Analysis of dose-response curv...
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| Veröffentlicht in: | The Journal of physiology 1977-08, Vol.270 (1), p.29-36 |
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| container_title | The Journal of physiology |
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| creator | Kondo, T Magee, D.F |
| description | 1. Ligation and division of the vessels supplying the stomach, except those from the spleen, result in greatly increased pepsin
secretion in response to pentagastrin, pilocarpine or 2-deoxy-D-glucose. 2. This effect was still present 6 months after initial
ligation. 3. Analysis of dose-response curves shows that for pepsin secretion the Vmax values were raised by this procedure.
4. Right-sided vessel ligation and division does not alter acid secretion in response to the stimuli used. 5. It is suspected
that the procedure of right-sided vessel ligation removes a non-competitive inhibitor mechanism to gastric pepsin secretion. |
| doi_str_mv | 10.1113/jphysiol.1977.sp011936 |
| format | Article |
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secretion in response to pentagastrin, pilocarpine or 2-deoxy-D-glucose. 2. This effect was still present 6 months after initial
ligation. 3. Analysis of dose-response curves shows that for pepsin secretion the Vmax values were raised by this procedure.
4. Right-sided vessel ligation and division does not alter acid secretion in response to the stimuli used. 5. It is suspected
that the procedure of right-sided vessel ligation removes a non-competitive inhibitor mechanism to gastric pepsin secretion.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1977.sp011936</identifier><identifier>PMID: 335045</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Deoxyglucose - pharmacology ; Dogs ; Dose-Response Relationship, Drug ; Gastric Mucosa - metabolism ; Ligation ; Pentagastrin - pharmacology ; Pepsin A - metabolism ; Pilocarpine - pharmacology ; Stimulation, Chemical ; Stomach - blood supply ; Stomach - innervation ; Vagotomy</subject><ispartof>The Journal of physiology, 1977-08, Vol.270 (1), p.29-36</ispartof><rights>1977 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5219-4134647b60e8fea036c0c9956e9dfc2d31f27cb1d2d0393fd05478e8ff4d9c833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1353415/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1353415/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/335045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondo, T</creatorcontrib><creatorcontrib>Magee, D.F</creatorcontrib><title>secretion of pepsin</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. Ligation and division of the vessels supplying the stomach, except those from the spleen, result in greatly increased pepsin
secretion in response to pentagastrin, pilocarpine or 2-deoxy-D-glucose. 2. This effect was still present 6 months after initial
ligation. 3. Analysis of dose-response curves shows that for pepsin secretion the Vmax values were raised by this procedure.
4. Right-sided vessel ligation and division does not alter acid secretion in response to the stimuli used. 5. It is suspected
that the procedure of right-sided vessel ligation removes a non-competitive inhibitor mechanism to gastric pepsin secretion.</description><subject>Animals</subject><subject>Deoxyglucose - pharmacology</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gastric Mucosa - metabolism</subject><subject>Ligation</subject><subject>Pentagastrin - pharmacology</subject><subject>Pepsin A - metabolism</subject><subject>Pilocarpine - pharmacology</subject><subject>Stimulation, Chemical</subject><subject>Stomach - blood supply</subject><subject>Stomach - innervation</subject><subject>Vagotomy</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1PGzEQxa2qXynlxLUqnHrb1OPxR3xBQqjQVkhUKpxHG6-dGG3Wi52A8t93wwKlt54szfu9Z_sNY5-BTwEAv970y22JqZ2CNWZaeg5gUb9iE5DaVsZYfM0mnAtRoVHwnn0o5YZzQG7tO_YWUXGpJuygeJf9OqbuKIWj3vcldh_Zm1C3xe8_nnvs-uzb1en36uLy_MfpyUXllABbSUCppZlr7mfB1xy1485apb1tghMNQhDGzaERDUeLoeFKmtnABtlYN0PcY8djbr-Zr3zjfLfOdUt9jqs6bynVkf5VurikRbojQIUS1BDw5TEgp9uNL2taxeJ829adT5tCBrXSUs4GUI-gy6mU7MPzJcBp1yY9tUm7NumpzcH46eUTn21jfYN8Msr3sfXb_wylq5-_dgNhOAj79xPLuFjex-xpdJXkol9vacAI6AE8HMFQJ6oXORa6_i12GxXWKC4M_gFjd551</recordid><startdate>19770801</startdate><enddate>19770801</enddate><creator>Kondo, T</creator><creator>Magee, D.F</creator><general>The Physiological Society</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19770801</creationdate><title>secretion of pepsin</title><author>Kondo, T ; Magee, D.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5219-4134647b60e8fea036c0c9956e9dfc2d31f27cb1d2d0393fd05478e8ff4d9c833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Deoxyglucose - pharmacology</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gastric Mucosa - metabolism</topic><topic>Ligation</topic><topic>Pentagastrin - pharmacology</topic><topic>Pepsin A - metabolism</topic><topic>Pilocarpine - pharmacology</topic><topic>Stimulation, Chemical</topic><topic>Stomach - blood supply</topic><topic>Stomach - innervation</topic><topic>Vagotomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, T</creatorcontrib><creatorcontrib>Magee, D.F</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, T</au><au>Magee, D.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>secretion of pepsin</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1977-08-01</date><risdate>1977</risdate><volume>270</volume><issue>1</issue><spage>29</spage><epage>36</epage><pages>29-36</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. Ligation and division of the vessels supplying the stomach, except those from the spleen, result in greatly increased pepsin
secretion in response to pentagastrin, pilocarpine or 2-deoxy-D-glucose. 2. This effect was still present 6 months after initial
ligation. 3. Analysis of dose-response curves shows that for pepsin secretion the Vmax values were raised by this procedure.
4. Right-sided vessel ligation and division does not alter acid secretion in response to the stimuli used. 5. It is suspected
that the procedure of right-sided vessel ligation removes a non-competitive inhibitor mechanism to gastric pepsin secretion.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>335045</pmid><doi>10.1113/jphysiol.1977.sp011936</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1977-08, Vol.270 (1), p.29-36 |
| issn | 0022-3751 1469-7793 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Deoxyglucose - pharmacology Dogs Dose-Response Relationship, Drug Gastric Mucosa - metabolism Ligation Pentagastrin - pharmacology Pepsin A - metabolism Pilocarpine - pharmacology Stimulation, Chemical Stomach - blood supply Stomach - innervation Vagotomy |
| title | secretion of pepsin |
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