Primary sclerosing cholangitis: a heterogenous disease

The clinical, radiologic and pathologic features of 37 patients diagnosed as having primary sclerosing cholangitis (PSC) were reviewed. Sixty-two per cent were men, and 35% had ulcerative colitis. The patients demonstrated considerable variability in their natural history and pathology. It appeared...

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Veröffentlicht in:	Annals of surgery 1982-08, Vol.196 (2), p.127-136
Hauptverfasser:	Thompson, H H, Pitt, H A, Tompkins, R K, Longmire, Jr, W P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biliary Tract - diagnostic imaging Biliary Tract - pathology Biliary Tract Diseases - diagnosis Cholangitis - complications Cholangitis - diagnosis Cholangitis - diagnostic imaging Cholangitis - pathology Cholangitis - surgery Humans Radiography
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creator	Thompson, H H Pitt, H A Tompkins, R K Longmire, Jr, W P
description	The clinical, radiologic and pathologic features of 37 patients diagnosed as having primary sclerosing cholangitis (PSC) were reviewed. Sixty-two per cent were men, and 35% had ulcerative colitis. The patients demonstrated considerable variability in their natural history and pathology. It appeared that they could be divided into four fairly distant groups (1) sclerosing cholangitis affecting primarily the distal common bile duct; (2) sclerosing cholangitis occurring soon after an attack of acute necrotizing cholangitis; (3) chronic diffuse sclerosing cholangitis; and (4) chronic diffuse sclerosing cholangitis associated with inflammatory bowel disease. It is suggested that the patients in these groups may have different etiologies, may respond to different treatment regimes, and may have different prognoses.
doi_str_mv	10.1097/00000658-198208000-00003
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Sixty-two per cent were men, and 35% had ulcerative colitis. The patients demonstrated considerable variability in their natural history and pathology. It appeared that they could be divided into four fairly distant groups (1) sclerosing cholangitis affecting primarily the distal common bile duct; (2) sclerosing cholangitis occurring soon after an attack of acute necrotizing cholangitis; (3) chronic diffuse sclerosing cholangitis; and (4) chronic diffuse sclerosing cholangitis associated with inflammatory bowel disease. 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Sixty-two per cent were men, and 35% had ulcerative colitis. The patients demonstrated considerable variability in their natural history and pathology. It appeared that they could be divided into four fairly distant groups (1) sclerosing cholangitis affecting primarily the distal common bile duct; (2) sclerosing cholangitis occurring soon after an attack of acute necrotizing cholangitis; (3) chronic diffuse sclerosing cholangitis; and (4) chronic diffuse sclerosing cholangitis associated with inflammatory bowel disease. 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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; PubMed Central
subjects	Biliary Tract - diagnostic imaging Biliary Tract - pathology Biliary Tract Diseases - diagnosis Cholangitis - complications Cholangitis - diagnosis Cholangitis - diagnostic imaging Cholangitis - pathology Cholangitis - surgery Humans Radiography
title	Primary sclerosing cholangitis: a heterogenous disease
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