A prospective analysis of laboratory tests and imaging studies to detect hepatic lesions
A prospective study of the ability of laboratory tests and liver imaging tests to detect hepatic metastases was performed. Eighty patients at risk for hepatic metastases but without clinical evidence of disease were tested with 13 laboratory tests and three liver imaging tests. No single laboratory...
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| Veröffentlicht in: | Ann. Surg.; (United States) 1982-02, Vol.195 (2), p.163-167 |
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| creator | Kemeny, M M Sugarbaker, P H Smith, T J Edwards, B K Shawker, T Vermess, M Jones, A E |
| description | A prospective study of the ability of laboratory tests and liver imaging tests to detect hepatic metastases was performed. Eighty patients at risk for hepatic metastases but without clinical evidence of disease were tested with 13 laboratory tests and three liver imaging tests. No single laboratory test had greater than 65% accuracy in the detection of hepatic lesions. No combination of the laboratory tests increased this accuracy. If the laboratory tests were used with one of the liver imaging tests, the accuracy was improved in some combinations to 76%. The CEA assay when analyzed in patients with colorectal primaries had an accuracy of 79%. The results show that the laboratory tests alone are not sufficiently accurate to detect liver metastases. Additional accuracy can be obtained by the combined use of a single liver imaging test and selected laboratory tests. Use of all the liver imaging tests and laboratory tests lowers the accuracy and increases the expense and thus is unnecessary. |
| doi_str_mv | 10.1097/00000658-198202000-00007 |
| format | Article |
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Eighty patients at risk for hepatic metastases but without clinical evidence of disease were tested with 13 laboratory tests and three liver imaging tests. No single laboratory test had greater than 65% accuracy in the detection of hepatic lesions. No combination of the laboratory tests increased this accuracy. If the laboratory tests were used with one of the liver imaging tests, the accuracy was improved in some combinations to 76%. The CEA assay when analyzed in patients with colorectal primaries had an accuracy of 79%. The results show that the laboratory tests alone are not sufficiently accurate to detect liver metastases. Additional accuracy can be obtained by the combined use of a single liver imaging test and selected laboratory tests. Use of all the liver imaging tests and laboratory tests lowers the accuracy and increases the expense and thus is unnecessary.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/00000658-198202000-00007</identifier><identifier>PMID: 7055392</identifier><language>eng</language><publisher>United States</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; 550602 - Medicine- External Radiation in Diagnostics- (1980-) ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOASSAY ; BODY ; Carcinoembryonic Antigen - analysis ; Colonic Neoplasms - pathology ; COMPARATIVE EVALUATIONS ; COMPUTERIZED TOMOGRAPHY ; COUNTING TECHNIQUES ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DIGESTIVE SYSTEM ; DISEASES ; GLANDS ; HOURS LIVING RADIOISOTOPES ; Humans ; INTERMEDIATE MASS NUCLEI ; ISOMERIC NUCLEI ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LIVER ; Liver - diagnostic imaging ; Liver - enzymology ; Liver Neoplasms - diagnosis ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - secondary ; METASTASES ; NEOPLASMS ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; Prospective Studies ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; Rectal Neoplasms - pathology ; SCINTISCANNING ; TECHNETIUM 99 ; TECHNETIUM COMPOUNDS ; TECHNETIUM ISOTOPES ; TOMOGRAPHY ; Tomography, X-Ray Computed ; TRANSITION ELEMENT COMPOUNDS ; ULTRASONOGRAPHY ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Ann. 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Surg.; (United States)</title><addtitle>Ann Surg</addtitle><description>A prospective study of the ability of laboratory tests and liver imaging tests to detect hepatic metastases was performed. Eighty patients at risk for hepatic metastases but without clinical evidence of disease were tested with 13 laboratory tests and three liver imaging tests. No single laboratory test had greater than 65% accuracy in the detection of hepatic lesions. No combination of the laboratory tests increased this accuracy. If the laboratory tests were used with one of the liver imaging tests, the accuracy was improved in some combinations to 76%. The CEA assay when analyzed in patients with colorectal primaries had an accuracy of 79%. The results show that the laboratory tests alone are not sufficiently accurate to detect liver metastases. Additional accuracy can be obtained by the combined use of a single liver imaging test and selected laboratory tests. Use of all the liver imaging tests and laboratory tests lowers the accuracy and increases the expense and thus is unnecessary.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>550602 - Medicine- External Radiation in Diagnostics- (1980-)</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BIOASSAY</subject><subject>BODY</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Colonic Neoplasms - pathology</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>COUNTING TECHNIQUES</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DISEASES</subject><subject>GLANDS</subject><subject>HOURS LIVING RADIOISOTOPES</subject><subject>Humans</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>ISOMERIC NUCLEI</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LIVER</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - enzymology</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - secondary</subject><subject>METASTASES</subject><subject>NEOPLASMS</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>Prospective Studies</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>Rectal Neoplasms - pathology</subject><subject>SCINTISCANNING</subject><subject>TECHNETIUM 99</subject><subject>TECHNETIUM COMPOUNDS</subject><subject>TECHNETIUM ISOTOPES</subject><subject>TOMOGRAPHY</subject><subject>Tomography, X-Ray Computed</subject><subject>TRANSITION ELEMENT COMPOUNDS</subject><subject>ULTRASONOGRAPHY</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1r3DAQFaUh3aT9CQXRQ29ORl-2dAmEkC8I9JJAbkKW5V0Vr-V4tIH999V2t0uji9CbN0_z5hFCGVwwMM0l7E6tdMWM5sDLo9ohzSeyYIoXmEn4TBYFEpU0gn8hZ4i_AZjU0JyS0waUEoYvyOs1neaEU_A5vgfqRjdsMSJNPR1cm2aX07ylOWDGUuxoXLtlHJcU86aLAWlOtAu5dNNVmFyOng4BYxrxKznp3YDh2-E-Jy93t883D9XTr_vHm-unykvJcxUEZ4oxaEWou950vu81cx0IqZRrG-9rWQut21rrwBx4J7zgIDwzHRipvDgnV3vdadOuQ-fDmGc32Gkuk85bm1y0HytjXNllerdMKC5FXQR-7AUS5mjRx-Jm5dM4FlO2ZgYk6EL6efhlTm-bsg27jujDMLgxpA3aRhjWGOCFqPdEX7aKc-iPkzCwu-jsv-jsMbq_UFNav__v5Nh4yEr8ATsnlbw</recordid><startdate>19820201</startdate><enddate>19820201</enddate><creator>Kemeny, M M</creator><creator>Sugarbaker, P H</creator><creator>Smith, T J</creator><creator>Edwards, B K</creator><creator>Shawker, T</creator><creator>Vermess, M</creator><creator>Jones, A E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19820201</creationdate><title>A prospective analysis of laboratory tests and imaging studies to detect hepatic lesions</title><author>Kemeny, M M ; Sugarbaker, P H ; Smith, T J ; Edwards, B K ; Shawker, T ; Vermess, M ; Jones, A E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-e3215110b3e6df9dcff81ad03455ab7cc646388b688e1a0ca3c3203c19d0945c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>550602 - Medicine- External Radiation in Diagnostics- (1980-)</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BIOASSAY</topic><topic>BODY</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Colonic Neoplasms - pathology</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>COUNTING TECHNIQUES</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DISEASES</topic><topic>GLANDS</topic><topic>HOURS LIVING RADIOISOTOPES</topic><topic>Humans</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>ISOMERIC NUCLEI</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LIVER</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - enzymology</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - secondary</topic><topic>METASTASES</topic><topic>NEOPLASMS</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>Prospective Studies</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>Rectal Neoplasms - pathology</topic><topic>SCINTISCANNING</topic><topic>TECHNETIUM 99</topic><topic>TECHNETIUM COMPOUNDS</topic><topic>TECHNETIUM ISOTOPES</topic><topic>TOMOGRAPHY</topic><topic>Tomography, X-Ray Computed</topic><topic>TRANSITION ELEMENT COMPOUNDS</topic><topic>ULTRASONOGRAPHY</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kemeny, M M</creatorcontrib><creatorcontrib>Sugarbaker, P H</creatorcontrib><creatorcontrib>Smith, T J</creatorcontrib><creatorcontrib>Edwards, B K</creatorcontrib><creatorcontrib>Shawker, T</creatorcontrib><creatorcontrib>Vermess, M</creatorcontrib><creatorcontrib>Jones, A E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ann. Surg.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kemeny, M M</au><au>Sugarbaker, P H</au><au>Smith, T J</au><au>Edwards, B K</au><au>Shawker, T</au><au>Vermess, M</au><au>Jones, A E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective analysis of laboratory tests and imaging studies to detect hepatic lesions</atitle><jtitle>Ann. Surg.; (United States)</jtitle><addtitle>Ann Surg</addtitle><date>1982-02-01</date><risdate>1982</risdate><volume>195</volume><issue>2</issue><spage>163</spage><epage>167</epage><pages>163-167</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><abstract>A prospective study of the ability of laboratory tests and liver imaging tests to detect hepatic metastases was performed. Eighty patients at risk for hepatic metastases but without clinical evidence of disease were tested with 13 laboratory tests and three liver imaging tests. No single laboratory test had greater than 65% accuracy in the detection of hepatic lesions. No combination of the laboratory tests increased this accuracy. If the laboratory tests were used with one of the liver imaging tests, the accuracy was improved in some combinations to 76%. The CEA assay when analyzed in patients with colorectal primaries had an accuracy of 79%. The results show that the laboratory tests alone are not sufficiently accurate to detect liver metastases. Additional accuracy can be obtained by the combined use of a single liver imaging test and selected laboratory tests. Use of all the liver imaging tests and laboratory tests lowers the accuracy and increases the expense and thus is unnecessary.</abstract><cop>United States</cop><pmid>7055392</pmid><doi>10.1097/00000658-198202000-00007</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Ann. Surg.; (United States), 1982-02, Vol.195 (2), p.163-167 |
| issn | 0003-4932 1528-1140 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics 550602 - Medicine- External Radiation in Diagnostics- (1980-) BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOASSAY BODY Carcinoembryonic Antigen - analysis Colonic Neoplasms - pathology COMPARATIVE EVALUATIONS COMPUTERIZED TOMOGRAPHY COUNTING TECHNIQUES DIAGNOSIS DIAGNOSTIC TECHNIQUES DIGESTIVE SYSTEM DISEASES GLANDS HOURS LIVING RADIOISOTOPES Humans INTERMEDIATE MASS NUCLEI ISOMERIC NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES LIVER Liver - diagnostic imaging Liver - enzymology Liver Neoplasms - diagnosis Liver Neoplasms - diagnostic imaging Liver Neoplasms - secondary METASTASES NEOPLASMS NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS Prospective Studies RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging Rectal Neoplasms - pathology SCINTISCANNING TECHNETIUM 99 TECHNETIUM COMPOUNDS TECHNETIUM ISOTOPES TOMOGRAPHY Tomography, X-Ray Computed TRANSITION ELEMENT COMPOUNDS ULTRASONOGRAPHY YEARS LIVING RADIOISOTOPES |
| title | A prospective analysis of laboratory tests and imaging studies to detect hepatic lesions |
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