Clinical studies of a perfluorochemical whole blood substitute (Fluosol-DA) Summary of 186 cases

After the experimental and phase one studies of our so-called "artificial blood," Fluosol-DA (20%), an emulsified mixture of perfluorodecalin and perfluorotripropylamine, were successfully completed, phase two and three clinical studies were carried out on 186 patients in Japan. The initia...

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Veröffentlicht in:	Annals of surgery 1982-01, Vol.195 (1), p.60-69
Hauptverfasser:	Mitsuno, T, Ohyanagi, H, Naito, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Blood Cell Count Blood Coagulation Blood Gas Analysis Blood Pressure Blood Substitutes - administration & dosage Child Clinical Trials as Topic Drug Combinations - administration & dosage Drug Evaluation Fluorocarbons - administration & dosage Humans Hydroxyethyl Starch Derivatives Japan Middle Aged Pulse
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container_title	Annals of surgery
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creator	Mitsuno, T Ohyanagi, H Naito, R
description	After the experimental and phase one studies of our so-called "artificial blood," Fluosol-DA (20%), an emulsified mixture of perfluorodecalin and perfluorotripropylamine, were successfully completed, phase two and three clinical studies were carried out on 186 patients in Japan. The initial dose was 20 ml/Kg body weight (BW), and additional 10 ml/Kg BW doses were applied as needed. Oxygen-supplying and plasma-extending effects were established. No untoward reaction was observed in any of the 186 cases except in a case that involved long-term repeated administration. Initial studies on FLuosol-DA suggest reasonable safety; however, additional clinical trials appear warranted.
doi_str_mv	10.1097/00000658-198201001-00010
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subjects	Adolescent Adult Aged Blood Cell Count Blood Coagulation Blood Gas Analysis Blood Pressure Blood Substitutes - administration & dosage Child Clinical Trials as Topic Drug Combinations - administration & dosage Drug Evaluation Fluorocarbons - administration & dosage Humans Hydroxyethyl Starch Derivatives Japan Middle Aged Pulse
title	Clinical studies of a perfluorochemical whole blood substitute (Fluosol-DA) Summary of 186 cases
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