Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells

We report that Id knockout mouse embryos display multiple cardiac defects, but mid-gestation lethality is rescued by the injection of 15 wild-type embryonic stem (ES) cells into mutant blastocysts. Myocardial markers altered in Id mutant cells are restored to normal throughout the chimeric myocardiu...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-10, Vol.306 (5694), p.247-252
Hauptverfasser:	Fraidenraich, Diego, Stillwell, Elizabeth, Romero, Elizabeth, Wilkes, David, Manova, Katia, Basson, Craig T., Benezra, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Birth defects Blastocyst Cardiology Cell Division Cell growth Cells, Cultured Classical genetics, quantitative genetics, hybrids DNA-Binding Proteins - genetics Embryo Loss Embryo, Mammalian - cytology Embryonic stem cells Embryos Endocardium Endothelial cells Epicardium Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation, Developmental Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Heart Heart - embryology Heart Defects, Congenital - embryology Heart Defects, Congenital - therapy Individualized Instruction Inhibitor of Differentiation Protein 1 Inhibitor of Differentiation Protein 2 Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - physiology Maternal-Fetal Exchange Mice Mice, Knockout Myocardium Myocardium - cytology Myocardium - metabolism Myocytes, Cardiac - cytology Oligonucleotide Array Sequence Analysis Pathology Pericardium - embryology Pericardium - metabolism Physiological aspects Pollution Pregnancy Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Pups Repressor Proteins - genetics Rodents Stem Cell Transplantation Stem cells Stem Cells - physiology Transcription Factors - genetics Vertebrata Wnt Proteins Wnt-5a Protein
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