Conductance changes associated with the secretory potential in the cockroach salivary gland
1. Conductance changes in the acini of the cockroach salivary gland have been examined during nerve stimulation by means of two intracellular electrodes placed in the same acinus, the first electrode being used for recording membrane potential and the second for current injection. 2. The transient h...
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| Veröffentlicht in: | The Journal of physiology 1974-02, Vol.236 (3), p.723-731 |
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| container_title | The Journal of physiology |
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| creator | Ginsborg, B. L. House, C. R. Silinsky, E. M. |
| description | 1. Conductance changes in the acini of the cockroach salivary gland have been examined during nerve stimulation by means of
two intracellular electrodes placed in the same acinus, the first electrode being used for recording membrane potential and
the second for current injection.
2. The transient hyperpolarization (secretory potential) in the acinus evoked by nerve stimuli is accompanied by a rise in
membrane conductance. The conductance, however, remains high for a longer period than that of the response.
3. Applying the analysis of Trautwein & Dudel (1958) to the secretory potentials recorded in the acinus (assumed to behave
electrically like a single cell) gives estimates of the `transmitter equilibrium potential'. The values indicate that the
neurotransmitter increases the membrane potassium conductance.
4. The hyperpolarization of the acinus evoked by 10 -6 M dopamine in the bathing fluid is also associated with an increase in membrane potassium conductance. |
| doi_str_mv | 10.1113/jphysiol.1974.sp010462 |
| format | Article |
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two intracellular electrodes placed in the same acinus, the first electrode being used for recording membrane potential and
the second for current injection.
2. The transient hyperpolarization (secretory potential) in the acinus evoked by nerve stimuli is accompanied by a rise in
membrane conductance. The conductance, however, remains high for a longer period than that of the response.
3. Applying the analysis of Trautwein & Dudel (1958) to the secretory potentials recorded in the acinus (assumed to behave
electrically like a single cell) gives estimates of the `transmitter equilibrium potential'. The values indicate that the
neurotransmitter increases the membrane potassium conductance.
4. The hyperpolarization of the acinus evoked by 10 -6 M dopamine in the bathing fluid is also associated with an increase in membrane potassium conductance.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1974.sp010462</identifier><identifier>PMID: 4822581</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Biological Transport, Active ; Cockroaches - physiology ; Dopamine - pharmacology ; Electric Conductivity ; Electric Stimulation ; Electrophysiology ; In Vitro Techniques ; Membrane Potentials ; Salivary Glands - drug effects ; Salivary Glands - physiology</subject><ispartof>The Journal of physiology, 1974-02, Vol.236 (3), p.723-731</ispartof><rights>1974 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5003-dd6f4e33b69f7ad72f65674407aa816f96251a4c9c78883a8a23bf9bf52be1973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350859/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350859/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4822581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ginsborg, B. L.</creatorcontrib><creatorcontrib>House, C. R.</creatorcontrib><creatorcontrib>Silinsky, E. M.</creatorcontrib><title>Conductance changes associated with the secretory potential in the cockroach salivary gland</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. Conductance changes in the acini of the cockroach salivary gland have been examined during nerve stimulation by means of
two intracellular electrodes placed in the same acinus, the first electrode being used for recording membrane potential and
the second for current injection.
2. The transient hyperpolarization (secretory potential) in the acinus evoked by nerve stimuli is accompanied by a rise in
membrane conductance. The conductance, however, remains high for a longer period than that of the response.
3. Applying the analysis of Trautwein & Dudel (1958) to the secretory potentials recorded in the acinus (assumed to behave
electrically like a single cell) gives estimates of the `transmitter equilibrium potential'. The values indicate that the
neurotransmitter increases the membrane potassium conductance.
4. The hyperpolarization of the acinus evoked by 10 -6 M dopamine in the bathing fluid is also associated with an increase in membrane potassium conductance.</description><subject>Animals</subject><subject>Biological Transport, Active</subject><subject>Cockroaches - physiology</subject><subject>Dopamine - pharmacology</subject><subject>Electric Conductivity</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>In Vitro Techniques</subject><subject>Membrane Potentials</subject><subject>Salivary Glands - drug effects</subject><subject>Salivary Glands - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS1EVYbCTwBlBatM_YhfGyQY8aoqwaKsWFiOczNxycTBznQ0_x6HTKuyY2XpnnOPz9WH0GuC14QQdnk7dsfkQ78mWlbrNGKCK0GfoBWphC6l1OwpWmFMackkJ8_Q85RuMSYMa32OzitFKVdkhX5uwtDs3WQHB4Xr7LCFVNiUgvN2gqY4-Kkrpg6KBC7CFOKxGMMEw-RtX_jhr-SC-xWDdV2RbO_vbPZsezs0L9BZa_sEL0_vBfrx6ePN5kt5_e3z183769JxjFnZNKKtgLFa6FbaRtJWcCGrCktrFRGtFpQTWzntpFKKWWUpq1tdt5zWkK9nF-jdkjvu6x00LreLtjdj9LvcxQTrzb_K4DuzDXeGMI4V1zngzSkght97SJPZ-eSgz0dA2CejKKOCc5KNYjG6GFKK0D58QrCZsZh7LGbGYu6x5MVXjys-rJ04ZP3Doh98D8f_TDU3V9_nAWWCScpyyNslpPPb7uAjmGVthgnT0WSfYWZ2_gF7gLF6</recordid><startdate>19740201</startdate><enddate>19740201</enddate><creator>Ginsborg, B. L.</creator><creator>House, C. R.</creator><creator>Silinsky, E. M.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19740201</creationdate><title>Conductance changes associated with the secretory potential in the cockroach salivary gland</title><author>Ginsborg, B. L. ; House, C. R. ; Silinsky, E. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5003-dd6f4e33b69f7ad72f65674407aa816f96251a4c9c78883a8a23bf9bf52be1973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Animals</topic><topic>Biological Transport, Active</topic><topic>Cockroaches - physiology</topic><topic>Dopamine - pharmacology</topic><topic>Electric Conductivity</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>In Vitro Techniques</topic><topic>Membrane Potentials</topic><topic>Salivary Glands - drug effects</topic><topic>Salivary Glands - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ginsborg, B. L.</creatorcontrib><creatorcontrib>House, C. R.</creatorcontrib><creatorcontrib>Silinsky, E. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ginsborg, B. L.</au><au>House, C. R.</au><au>Silinsky, E. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conductance changes associated with the secretory potential in the cockroach salivary gland</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1974-02-01</date><risdate>1974</risdate><volume>236</volume><issue>3</issue><spage>723</spage><epage>731</epage><pages>723-731</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. Conductance changes in the acini of the cockroach salivary gland have been examined during nerve stimulation by means of
two intracellular electrodes placed in the same acinus, the first electrode being used for recording membrane potential and
the second for current injection.
2. The transient hyperpolarization (secretory potential) in the acinus evoked by nerve stimuli is accompanied by a rise in
membrane conductance. The conductance, however, remains high for a longer period than that of the response.
3. Applying the analysis of Trautwein & Dudel (1958) to the secretory potentials recorded in the acinus (assumed to behave
electrically like a single cell) gives estimates of the `transmitter equilibrium potential'. The values indicate that the
neurotransmitter increases the membrane potassium conductance.
4. The hyperpolarization of the acinus evoked by 10 -6 M dopamine in the bathing fluid is also associated with an increase in membrane potassium conductance.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>4822581</pmid><doi>10.1113/jphysiol.1974.sp010462</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0022-3751 1469-7793 |
| language | eng |
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| source | MEDLINE; Wiley Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biological Transport, Active Cockroaches - physiology Dopamine - pharmacology Electric Conductivity Electric Stimulation Electrophysiology In Vitro Techniques Membrane Potentials Salivary Glands - drug effects Salivary Glands - physiology |
| title | Conductance changes associated with the secretory potential in the cockroach salivary gland |
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