The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride
Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 m N citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate. 1. Increase in concentration of sodium citrate in the range 0-125 m N gave increasing outputs of acid and chloride. 2. T...
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| Veröffentlicht in: | The Journal of physiology 1973-04, Vol.230 (1), p.171-184 |
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| container_title | The Journal of physiology |
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| creator | Hunt, J. N. Knox, M. T. |
| description | Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 m N citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate.
1. Increase in concentration of sodium citrate in the range 0-125 m N gave increasing outputs of acid and chloride.
2. The more acid the meal for any given citrate ion concentration, the less the output of acid and chloride.
3. The greater the concentration of an acid citrate salt, the less the output of acid.
4. There was evidence of loss of acid from the stomach by diffusion with the more acid meals. |
| doi_str_mv | 10.1113/jphysiol.1973.sp010181 |
| format | Article |
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1. Increase in concentration of sodium citrate in the range 0-125 m N gave increasing outputs of acid and chloride.
2. The more acid the meal for any given citrate ion concentration, the less the output of acid and chloride.
3. The greater the concentration of an acid citrate salt, the less the output of acid.
4. There was evidence of loss of acid from the stomach by diffusion with the more acid meals.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1973.sp010181</identifier><identifier>PMID: 4702420</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Chlorides - metabolism ; Citrates - administration & dosage ; Citrates - pharmacology ; Diffusion ; Gastric Juice - metabolism ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Humans ; Hydrogen-Ion Concentration ; Male ; Secretory Rate - drug effects ; Sensory Receptor Cells ; Sodium ; Stomach - innervation</subject><ispartof>The Journal of physiology, 1973-04, Vol.230 (1), p.171-184</ispartof><rights>1973 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5001-257459b9afeaab8b894ebaebc6a1c087063ae969a393ec47c7fbfe7be74b2d953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350392/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350392/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,1412,27905,27906,45555,45556,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4702420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hunt, J. N.</creatorcontrib><creatorcontrib>Knox, M. T.</creatorcontrib><title>The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 m N citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate.
1. Increase in concentration of sodium citrate in the range 0-125 m N gave increasing outputs of acid and chloride.
2. The more acid the meal for any given citrate ion concentration, the less the output of acid and chloride.
3. The greater the concentration of an acid citrate salt, the less the output of acid.
4. There was evidence of loss of acid from the stomach by diffusion with the more acid meals.</description><subject>Chlorides - metabolism</subject><subject>Citrates - administration & dosage</subject><subject>Citrates - pharmacology</subject><subject>Diffusion</subject><subject>Gastric Juice - metabolism</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Secretory Rate - drug effects</subject><subject>Sensory Receptor Cells</subject><subject>Sodium</subject><subject>Stomach - innervation</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS0EKtvCTwD5BKcsnjiJ4wsSVFCoKpXDcrZsZ7JxSeIQJ1T773HIdkVvPVnjee-bGT1C3gLbAgD_cDc0h-B8uwUp-DYMDBiU8IxsICtkIoTkz8mGsTRNuMjhJTkP4Y4x4EzKM3KWCZZmKduQX7sGKdY12on6mlo3jc5SbV1FdV9RNwUafOXmjgbdxsL1dMIw0Q51G6iPVfTvdfhn8_M0zFEUQSfCAm1aP7oKX5EXdXTh6-N7QX5-_bK7_Jbc3F59v_x0k9g8bpikuchyaaSuUWtTmlJmaDQaW2iwrBSs4BplITWXHG0mrKhNjcKgyExayZxfkI8rd5hNh5XFfhp1q4bRdXo8KK-detzpXaP2_o8CnjMu0wh4dwSM_vccz1WdCxbbVvfo56BKkJBBXkRhsQrt6EMYsT4NAaaWmNRDTGqJST3EFI1v_l_xZDvmEvuf1_69a_HwRKraXf9YPlLOAMQy5P0Kady-uXcjqtUWvHU4HVTUKVCL8i-UILas</recordid><startdate>19730401</startdate><enddate>19730401</enddate><creator>Hunt, J. N.</creator><creator>Knox, M. T.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19730401</creationdate><title>The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride</title><author>Hunt, J. N. ; Knox, M. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5001-257459b9afeaab8b894ebaebc6a1c087063ae969a393ec47c7fbfe7be74b2d953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Chlorides - metabolism</topic><topic>Citrates - administration & dosage</topic><topic>Citrates - pharmacology</topic><topic>Diffusion</topic><topic>Gastric Juice - metabolism</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Secretory Rate - drug effects</topic><topic>Sensory Receptor Cells</topic><topic>Sodium</topic><topic>Stomach - innervation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunt, J. N.</creatorcontrib><creatorcontrib>Knox, M. T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hunt, J. N.</au><au>Knox, M. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1973-04-01</date><risdate>1973</risdate><volume>230</volume><issue>1</issue><spage>171</spage><epage>184</epage><pages>171-184</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 m N citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate.
1. Increase in concentration of sodium citrate in the range 0-125 m N gave increasing outputs of acid and chloride.
2. The more acid the meal for any given citrate ion concentration, the less the output of acid and chloride.
3. The greater the concentration of an acid citrate salt, the less the output of acid.
4. There was evidence of loss of acid from the stomach by diffusion with the more acid meals.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>4702420</pmid><doi>10.1113/jphysiol.1973.sp010181</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1973-04, Vol.230 (1), p.171-184 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1350392 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Chlorides - metabolism Citrates - administration & dosage Citrates - pharmacology Diffusion Gastric Juice - metabolism Gastric Mucosa - drug effects Gastric Mucosa - metabolism Humans Hydrogen-Ion Concentration Male Secretory Rate - drug effects Sensory Receptor Cells Sodium Stomach - innervation |
| title | The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride |
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