Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context
MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-pr...
Gespeichert in:
| Veröffentlicht in: | Nucleic acids research 2006-01, Vol.34 (1), p.D568-D571 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | D571 |
|---|---|
| container_issue | 1 |
| container_start_page | D568 |
| container_title | Nucleic acids research |
| container_volume | 34 |
| creator | Ruepp, Andreas Doudieu, Octave Noubibou van den Oever, Jos Brauner, Barbara Dunger-Kaltenbach, Irmtraud Fobo, Gisela Frishman, Goar Montrone, Corinna Skornia, Christine Wanka, Steffi Rattei, Thomas Pagel, Philipp Riley, Louise Frishman, Dmitrij Surmeli, Dimitrij Tetko, Igor V Oesterheld, Matthias Stümpflen, Volker Mewes, H. Werner |
| description | MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-protein interaction database (MPPI) and a database of mammalian protein complexes is interconnected with MfunGD. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme which is widely used for the analysis of protein networks. The dataset is also supplemented with information about the literature that was used in the annotation process as well as links to the SIMAP Fasta database, the Pedant protein analysis system and cross-references to external resources. Proteins that so far were not manually inspected are annotated automatically by a graphical probabilistic model and/or superparamagnetic clustering. The database is continuously expanding to include the rapidly growing amount of functional information about gene products from mouse. MfunGD is implemented in GenRE, a J2EE-based component-oriented multi-tier architecture following the separation of concern principle. |
| doi_str_mv | 10.1093/nar/gkj074 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1347437</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17427850</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-4e7fdec627f9b63e39af10a24227544636b7c0253d79f54b089fd65810d168153</originalsourceid><addsrcrecordid>eNqFks1uEzEUhUcIRENhwwPAiAUCpKHX_2MWSKghKVIrFlAJdWM5EztxOrGD7UHw9jhM1AKbruyr8-lK59xTVU8RvEUgyYnX8WR1vQFB71UTRDhuqOT4fjUBAqxBQNuj6lFKGwBEEaMPqyPESYskoZMqXYQhmXo2-C674HVfz40PW1NPddYLXaRXF3bw8-nrd7W9hbT3Iev9UAdb72LIxvlUO1_ntal7t1rnvVAGF-vO9P3Q6_IJPpuf-XH1wOo-mSeH97i6nH38enrWnH-efzr9cN50DIvcUCPs0nQcCysXnBgitUWgMcVYMEo54QvRAWZkKaRldAGttEvOWgRLxFvEyHH1fty7GxZbs-yMz1H3ahfdVsdfKmin_lW8W6tV-KEQoYISURa8PCyI4ftgUlZbl_ZutDclNsUFByKovBNEsm0Fa-ndoKBYtAwK-OI_cBOGWKJPCgMUk_KPwTcj1MWQUjT2xhsCta-GKtVQYzUK_OzvNG7RQxcK0IyAS-VKN7qO18UoEUydfbtSV0BhyuZCzQr_fOStDkqvokvq8gsGRAAB45Ji8hs_-c2r</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>200581915</pqid></control><display><type>article</type><title>Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context</title><source>Oxford Journals Open Access Collection</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Ruepp, Andreas ; Doudieu, Octave Noubibou ; van den Oever, Jos ; Brauner, Barbara ; Dunger-Kaltenbach, Irmtraud ; Fobo, Gisela ; Frishman, Goar ; Montrone, Corinna ; Skornia, Christine ; Wanka, Steffi ; Rattei, Thomas ; Pagel, Philipp ; Riley, Louise ; Frishman, Dmitrij ; Surmeli, Dimitrij ; Tetko, Igor V ; Oesterheld, Matthias ; Stümpflen, Volker ; Mewes, H. Werner</creator><creatorcontrib>Ruepp, Andreas ; Doudieu, Octave Noubibou ; van den Oever, Jos ; Brauner, Barbara ; Dunger-Kaltenbach, Irmtraud ; Fobo, Gisela ; Frishman, Goar ; Montrone, Corinna ; Skornia, Christine ; Wanka, Steffi ; Rattei, Thomas ; Pagel, Philipp ; Riley, Louise ; Frishman, Dmitrij ; Surmeli, Dimitrij ; Tetko, Igor V ; Oesterheld, Matthias ; Stümpflen, Volker ; Mewes, H. Werner</creatorcontrib><description>MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-protein interaction database (MPPI) and a database of mammalian protein complexes is interconnected with MfunGD. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme which is widely used for the analysis of protein networks. The dataset is also supplemented with information about the literature that was used in the annotation process as well as links to the SIMAP Fasta database, the Pedant protein analysis system and cross-references to external resources. Proteins that so far were not manually inspected are annotated automatically by a graphical probabilistic model and/or superparamagnetic clustering. The database is continuously expanding to include the rapidly growing amount of functional information about gene products from mouse. MfunGD is implemented in GenRE, a J2EE-based component-oriented multi-tier architecture following the separation of concern principle.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/gkj074</identifier><identifier>PMID: 16381934</identifier><identifier>CODEN: NARHAD</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Databases, Genetic ; Genomics ; Internet ; Mice - genetics ; Multiprotein Complexes - chemistry ; Multiprotein Complexes - genetics ; Multiprotein Complexes - physiology ; Proteomics ; Software ; User-Computer Interface</subject><ispartof>Nucleic acids research, 2006-01, Vol.34 (1), p.D568-D571</ispartof><rights>Copyright Oxford University Press(England) Jan 1, 2006</rights><rights>The Author 2006. Published by Oxford University Press. All rights reserved 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-4e7fdec627f9b63e39af10a24227544636b7c0253d79f54b089fd65810d168153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347437/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347437/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16381934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruepp, Andreas</creatorcontrib><creatorcontrib>Doudieu, Octave Noubibou</creatorcontrib><creatorcontrib>van den Oever, Jos</creatorcontrib><creatorcontrib>Brauner, Barbara</creatorcontrib><creatorcontrib>Dunger-Kaltenbach, Irmtraud</creatorcontrib><creatorcontrib>Fobo, Gisela</creatorcontrib><creatorcontrib>Frishman, Goar</creatorcontrib><creatorcontrib>Montrone, Corinna</creatorcontrib><creatorcontrib>Skornia, Christine</creatorcontrib><creatorcontrib>Wanka, Steffi</creatorcontrib><creatorcontrib>Rattei, Thomas</creatorcontrib><creatorcontrib>Pagel, Philipp</creatorcontrib><creatorcontrib>Riley, Louise</creatorcontrib><creatorcontrib>Frishman, Dmitrij</creatorcontrib><creatorcontrib>Surmeli, Dimitrij</creatorcontrib><creatorcontrib>Tetko, Igor V</creatorcontrib><creatorcontrib>Oesterheld, Matthias</creatorcontrib><creatorcontrib>Stümpflen, Volker</creatorcontrib><creatorcontrib>Mewes, H. Werner</creatorcontrib><title>Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context</title><title>Nucleic acids research</title><addtitle>Nucl. Acids Res</addtitle><description>MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-protein interaction database (MPPI) and a database of mammalian protein complexes is interconnected with MfunGD. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme which is widely used for the analysis of protein networks. The dataset is also supplemented with information about the literature that was used in the annotation process as well as links to the SIMAP Fasta database, the Pedant protein analysis system and cross-references to external resources. Proteins that so far were not manually inspected are annotated automatically by a graphical probabilistic model and/or superparamagnetic clustering. The database is continuously expanding to include the rapidly growing amount of functional information about gene products from mouse. MfunGD is implemented in GenRE, a J2EE-based component-oriented multi-tier architecture following the separation of concern principle.</description><subject>Animals</subject><subject>Databases, Genetic</subject><subject>Genomics</subject><subject>Internet</subject><subject>Mice - genetics</subject><subject>Multiprotein Complexes - chemistry</subject><subject>Multiprotein Complexes - genetics</subject><subject>Multiprotein Complexes - physiology</subject><subject>Proteomics</subject><subject>Software</subject><subject>User-Computer Interface</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1uEzEUhUcIRENhwwPAiAUCpKHX_2MWSKghKVIrFlAJdWM5EztxOrGD7UHw9jhM1AKbruyr8-lK59xTVU8RvEUgyYnX8WR1vQFB71UTRDhuqOT4fjUBAqxBQNuj6lFKGwBEEaMPqyPESYskoZMqXYQhmXo2-C674HVfz40PW1NPddYLXaRXF3bw8-nrd7W9hbT3Iev9UAdb72LIxvlUO1_ntal7t1rnvVAGF-vO9P3Q6_IJPpuf-XH1wOo-mSeH97i6nH38enrWnH-efzr9cN50DIvcUCPs0nQcCysXnBgitUWgMcVYMEo54QvRAWZkKaRldAGttEvOWgRLxFvEyHH1fty7GxZbs-yMz1H3ahfdVsdfKmin_lW8W6tV-KEQoYISURa8PCyI4ftgUlZbl_ZutDclNsUFByKovBNEsm0Fa-ndoKBYtAwK-OI_cBOGWKJPCgMUk_KPwTcj1MWQUjT2xhsCta-GKtVQYzUK_OzvNG7RQxcK0IyAS-VKN7qO18UoEUydfbtSV0BhyuZCzQr_fOStDkqvokvq8gsGRAAB45Ji8hs_-c2r</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Ruepp, Andreas</creator><creator>Doudieu, Octave Noubibou</creator><creator>van den Oever, Jos</creator><creator>Brauner, Barbara</creator><creator>Dunger-Kaltenbach, Irmtraud</creator><creator>Fobo, Gisela</creator><creator>Frishman, Goar</creator><creator>Montrone, Corinna</creator><creator>Skornia, Christine</creator><creator>Wanka, Steffi</creator><creator>Rattei, Thomas</creator><creator>Pagel, Philipp</creator><creator>Riley, Louise</creator><creator>Frishman, Dmitrij</creator><creator>Surmeli, Dimitrij</creator><creator>Tetko, Igor V</creator><creator>Oesterheld, Matthias</creator><creator>Stümpflen, Volker</creator><creator>Mewes, H. Werner</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060101</creationdate><title>Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context</title><author>Ruepp, Andreas ; Doudieu, Octave Noubibou ; van den Oever, Jos ; Brauner, Barbara ; Dunger-Kaltenbach, Irmtraud ; Fobo, Gisela ; Frishman, Goar ; Montrone, Corinna ; Skornia, Christine ; Wanka, Steffi ; Rattei, Thomas ; Pagel, Philipp ; Riley, Louise ; Frishman, Dmitrij ; Surmeli, Dimitrij ; Tetko, Igor V ; Oesterheld, Matthias ; Stümpflen, Volker ; Mewes, H. Werner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-4e7fdec627f9b63e39af10a24227544636b7c0253d79f54b089fd65810d168153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Databases, Genetic</topic><topic>Genomics</topic><topic>Internet</topic><topic>Mice - genetics</topic><topic>Multiprotein Complexes - chemistry</topic><topic>Multiprotein Complexes - genetics</topic><topic>Multiprotein Complexes - physiology</topic><topic>Proteomics</topic><topic>Software</topic><topic>User-Computer Interface</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruepp, Andreas</creatorcontrib><creatorcontrib>Doudieu, Octave Noubibou</creatorcontrib><creatorcontrib>van den Oever, Jos</creatorcontrib><creatorcontrib>Brauner, Barbara</creatorcontrib><creatorcontrib>Dunger-Kaltenbach, Irmtraud</creatorcontrib><creatorcontrib>Fobo, Gisela</creatorcontrib><creatorcontrib>Frishman, Goar</creatorcontrib><creatorcontrib>Montrone, Corinna</creatorcontrib><creatorcontrib>Skornia, Christine</creatorcontrib><creatorcontrib>Wanka, Steffi</creatorcontrib><creatorcontrib>Rattei, Thomas</creatorcontrib><creatorcontrib>Pagel, Philipp</creatorcontrib><creatorcontrib>Riley, Louise</creatorcontrib><creatorcontrib>Frishman, Dmitrij</creatorcontrib><creatorcontrib>Surmeli, Dimitrij</creatorcontrib><creatorcontrib>Tetko, Igor V</creatorcontrib><creatorcontrib>Oesterheld, Matthias</creatorcontrib><creatorcontrib>Stümpflen, Volker</creatorcontrib><creatorcontrib>Mewes, H. Werner</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruepp, Andreas</au><au>Doudieu, Octave Noubibou</au><au>van den Oever, Jos</au><au>Brauner, Barbara</au><au>Dunger-Kaltenbach, Irmtraud</au><au>Fobo, Gisela</au><au>Frishman, Goar</au><au>Montrone, Corinna</au><au>Skornia, Christine</au><au>Wanka, Steffi</au><au>Rattei, Thomas</au><au>Pagel, Philipp</au><au>Riley, Louise</au><au>Frishman, Dmitrij</au><au>Surmeli, Dimitrij</au><au>Tetko, Igor V</au><au>Oesterheld, Matthias</au><au>Stümpflen, Volker</au><au>Mewes, H. Werner</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucl. Acids Res</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>34</volume><issue>1</issue><spage>D568</spage><epage>D571</epage><pages>D568-D571</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><coden>NARHAD</coden><abstract>MfunGD (http://mips.gsf.de/genre/proj/mfungd/) provides a resource for annotated mouse proteins and their occurrence in protein networks. Manual annotation concentrates on proteins which are found to interact physically with other proteins. Accordingly, manually curated information from a protein-protein interaction database (MPPI) and a database of mammalian protein complexes is interconnected with MfunGD. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme which is widely used for the analysis of protein networks. The dataset is also supplemented with information about the literature that was used in the annotation process as well as links to the SIMAP Fasta database, the Pedant protein analysis system and cross-references to external resources. Proteins that so far were not manually inspected are annotated automatically by a graphical probabilistic model and/or superparamagnetic clustering. The database is continuously expanding to include the rapidly growing amount of functional information about gene products from mouse. MfunGD is implemented in GenRE, a J2EE-based component-oriented multi-tier architecture following the separation of concern principle.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>16381934</pmid><doi>10.1093/nar/gkj074</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1048 |
| ispartof | Nucleic acids research, 2006-01, Vol.34 (1), p.D568-D571 |
| issn | 0305-1048 1362-4962 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1347437 |
| source | Oxford Journals Open Access Collection; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Databases, Genetic Genomics Internet Mice - genetics Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - physiology Proteomics Software User-Computer Interface |
| title | Mouse Functional Genome Database (MfunGD): functional annotation of proteins in the light of their cellular context |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A31%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mouse%20Functional%20Genome%20Database%20(MfunGD):%20functional%20annotation%20of%20proteins%20in%20the%20light%20of%20their%20cellular%20context&rft.jtitle=Nucleic%20acids%20research&rft.au=Ruepp,%20Andreas&rft.date=2006-01-01&rft.volume=34&rft.issue=1&rft.spage=D568&rft.epage=D571&rft.pages=D568-D571&rft.issn=0305-1048&rft.eissn=1362-4962&rft.coden=NARHAD&rft_id=info:doi/10.1093/nar/gkj074&rft_dat=%3Cproquest_pubme%3E17427850%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=200581915&rft_id=info:pmid/16381934&rfr_iscdi=true |