Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress

The rac1 GTPase and the p66shc adaptor protein regulate intracellular levels of reactive oxygen species (ROS). We examined the relationship between rac1 and p66shc. Expression of constitutively active rac1 (rac1V12) increased phosphorylation, reduced ubiquitination, and increased stability of p66shc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular biology of the cell 2006-01, Vol.17 (1), p.122-129
Hauptverfasser:	Khanday, Firdous A, Yamamori, Tohru, Mattagajasingh, Ilwola, Zhang, Zhe, Bugayenko, Artem, Naqvi, Asma, Santhanam, Lakshmi, Nabi, Nusrat, Kasuno, Kenji, Day, Billy W, Irani, Kaikobad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Cercopithecus aethiops Enzyme Stability Mice Oxidative Stress p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rats Serine - genetics Serine - metabolism Shc Signaling Adaptor Proteins Src Homology 2 Domain-Containing, Transforming Protein 1 Threonine - genetics Threonine - metabolism Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!