Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth

The ErbB1 and ErbB2 receptors are oncogenes with therapeutic significance in human cancer, whereas the transforming potential of the related ErbB4 receptor has remained controversial. Here, we have addressed whether four alternatively spliced ErbB4 isoforms differ in regulating cellular responses re...

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Veröffentlicht in:	Molecular biology of the cell 2006-01, Vol.17 (1), p.67-79
Hauptverfasser:	Määttä, Jorma A, Sundvall, Maria, Junttila, Teemu T, Peri, Liisa, Laine, V Jukka O, Isola, Jorma, Egeblad, Mikala, Elenius, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM17 Protein Adult Aged Aged, 80 and over Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Cell Line, Tumor Cell Membrane - metabolism Cell Proliferation Cell Survival Dimerization Endopeptidases - metabolism Gene Expression Regulation, Neoplastic Humans Ligands Middle Aged Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Phosphorylation Phosphotyrosine - metabolism Protein Isoforms - genetics Protein Isoforms - metabolism Protein Processing, Post-Translational Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-4 Signal Transduction Solubility
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