Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast
The estrogen receptor (ER) level in carcinoma of the breast is a useful predictor of response to hormonal therapy. Metastatic disease may not have the same level of ER as the primary. In a series of 37 patients who had simultaneous ER determination in both primary neoplasm and regional nodal metasta...
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| Veröffentlicht in: | Annals of surgery 1979-07, Vol.190 (1), p.69-71 |
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| container_title | Annals of surgery |
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| creator | Hoehn, J L Plotka, E D Dickson, K B |
| description | The estrogen receptor (ER) level in carcinoma of the breast is a useful predictor of response to hormonal therapy. Metastatic disease may not have the same level of ER as the primary. In a series of 37 patients who had simultaneous ER determination in both primary neoplasm and regional nodal metastasis there was 81% agreement. The true ER character of the tumor would have been missed in seven patients if only the primary tumor had been sampled. The possible reasons for this discrepancy are discussed. We feel that the nodal metastatic deposit may reflect the true nature of the ER status because it represents a purer concentration of tumor cells as well as representing the aggressive element of the tumor. |
| doi_str_mv | 10.1097/00000658-197907000-00015 |
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Metastatic disease may not have the same level of ER as the primary. In a series of 37 patients who had simultaneous ER determination in both primary neoplasm and regional nodal metastasis there was 81% agreement. The true ER character of the tumor would have been missed in seven patients if only the primary tumor had been sampled. The possible reasons for this discrepancy are discussed. We feel that the nodal metastatic deposit may reflect the true nature of the ER status because it represents a purer concentration of tumor cells as well as representing the aggressive element of the tumor.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/00000658-197907000-00015</identifier><identifier>PMID: 464682</identifier><language>eng</language><publisher>United States</publisher><subject>Axilla ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinoma - metabolism ; Carcinoma - pathology ; Female ; Humans ; Lymph Nodes ; Lymphatic Metastasis ; Menopause ; Neoplasm Metastasis - metabolism ; Receptors, Estrogen - metabolism</subject><ispartof>Annals of surgery, 1979-07, Vol.190 (1), p.69-71</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-402a56e37951129e314d255f9b53ac7a4a1666cd190d4830e15cefd4de4a23613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1344460/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1344460/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/464682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoehn, J L</creatorcontrib><creatorcontrib>Plotka, E D</creatorcontrib><creatorcontrib>Dickson, K B</creatorcontrib><title>Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>The estrogen receptor (ER) level in carcinoma of the breast is a useful predictor of response to hormonal therapy. Metastatic disease may not have the same level of ER as the primary. In a series of 37 patients who had simultaneous ER determination in both primary neoplasm and regional nodal metastasis there was 81% agreement. The true ER character of the tumor would have been missed in seven patients if only the primary tumor had been sampled. The possible reasons for this discrepancy are discussed. We feel that the nodal metastatic deposit may reflect the true nature of the ER status because it represents a purer concentration of tumor cells as well as representing the aggressive element of the tumor.</description><subject>Axilla</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Lymph Nodes</subject><subject>Lymphatic Metastasis</subject><subject>Menopause</subject><subject>Neoplasm Metastasis - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUuv0zAQhS3Eq1z4Byy8YhfwxGMn2SCh6vKQrsQG1tbUmfQaJXax0yvx73FpqcCSZXnOmeORPyEkqLeghu6dOi1r-gaGblBdvTR1g3kkNmDaWgZUj8Wm1nSDg26fixel_KgO7FX3TDxFi7ZvN4K2aTlQDiVFmSbJZc1pz1Fm9nxYU5YzP_BcZIjykMNC-ZekOFZ5H1KkWS68UllpDV56yj7EtNApaL1nuctctZfiyURz4VeX80Z8_3j7bfu5ufv66cv2w13jEXBtULVkLOtuMADtwBpwbI2Zhp3R5DtCAmutH2FQI_ZaMRjP04gjI7Xagr4R78-5h-Nu4dFzXDPN7jK1SxTc_0oM926fHhxoRLSqBry5BOT081h_wi2heJ5nipyOxXVobQ_9ydifjT6nUjJP10dAuRMd95eOu9Jxf-jU1tf_DnltPOPQvwFg1YyM</recordid><startdate>19790701</startdate><enddate>19790701</enddate><creator>Hoehn, J L</creator><creator>Plotka, E D</creator><creator>Dickson, K B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19790701</creationdate><title>Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast</title><author>Hoehn, J L ; Plotka, E D ; Dickson, K B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-402a56e37951129e314d255f9b53ac7a4a1666cd190d4830e15cefd4de4a23613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Axilla</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Lymph Nodes</topic><topic>Lymphatic Metastasis</topic><topic>Menopause</topic><topic>Neoplasm Metastasis - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoehn, J L</creatorcontrib><creatorcontrib>Plotka, E D</creatorcontrib><creatorcontrib>Dickson, K B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoehn, J L</au><au>Plotka, E D</au><au>Dickson, K B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>1979-07-01</date><risdate>1979</risdate><volume>190</volume><issue>1</issue><spage>69</spage><epage>71</epage><pages>69-71</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><abstract>The estrogen receptor (ER) level in carcinoma of the breast is a useful predictor of response to hormonal therapy. Metastatic disease may not have the same level of ER as the primary. In a series of 37 patients who had simultaneous ER determination in both primary neoplasm and regional nodal metastasis there was 81% agreement. The true ER character of the tumor would have been missed in seven patients if only the primary tumor had been sampled. The possible reasons for this discrepancy are discussed. We feel that the nodal metastatic deposit may reflect the true nature of the ER status because it represents a purer concentration of tumor cells as well as representing the aggressive element of the tumor.</abstract><cop>United States</cop><pmid>464682</pmid><doi>10.1097/00000658-197907000-00015</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of surgery, 1979-07, Vol.190 (1), p.69-71 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Axilla Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma - metabolism Carcinoma - pathology Female Humans Lymph Nodes Lymphatic Metastasis Menopause Neoplasm Metastasis - metabolism Receptors, Estrogen - metabolism |
| title | Comparison of estrogen receptor levels in primary and regional metastatic carcinoma of the breast |
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