Mechanism responsible for the cardiovascular depressant. Effect of protamine sulfate

The mechanism of protamine-induced hypotension and bradycardia was investigated in anesthetized, heparinized dogs. Several groups of animals with intact circulation were studied for their responses to protamine under control conditions and following the administration of various pharmacological agen...

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Veröffentlicht in:	Annals of surgery 1974-08, Vol.180 (2), p.232-235
Hauptverfasser:	Fadali, M A, Ledbetter, M, Papacostas, C A, Duke, L J, Lemole, G M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Blood Pressure - drug effects Bradycardia - chemically induced Cardiac Output - drug effects Central Venous Pressure - drug effects Dogs Extracorporeal Circulation Heart - drug effects Heart Ventricles - drug effects Heparin - pharmacology Hexamethonium Compounds - pharmacology Hypotension - chemically induced p-Methoxy-N-methylphenethylamine - pharmacology Phenoxybenzamine - pharmacology Propranolol - pharmacology Protamines - adverse effects Protamines - pharmacology Ventricular Function
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