Association of SIGNR1 with TLR4–MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria

SIGNR1, a member of a new family of mouse C-type lectins, is expressed at high levels in macrophages (Mϕ) within the splenic marginal zone, lymph node medulla, and in some strains, in peritoneal cavity. We previously reported that SIGNR1 captures gram-negative bacteria, such as Escherichia coli and...

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Veröffentlicht in:	International immunology 2005-07, Vol.17 (7), p.827-836
Hauptverfasser:	Nagaoka, Koji, Takahara, Kazuhiko, Tanaka, Kay, Yoshida, Hideo, Steinman, Ralph M., Saitoh, Shin-ichiro, Akashi-Takamura, Sachiko, Miyake, Kensuke, Kang, Young Sun, Park, Chae Gyu, Inaba, Kayo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Candida albicans Cell Adhesion Molecules - immunology Cell Line CPS capsular pneumococcal polysaccharide Cytokines - biosynthesis DC-SIGN dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin binding receptor DC dendritic cell Escherichia coli Escherichia coli - immunology Female Gene Expression gram-negative bacteria hDC-SIGN human DC-SIGN HEK human embryonic kidney KDO 2-keto-3-deoxy octonate LBP LPS-binding protein lectin Lectins, C-Type - genetics Lectins, C-Type - immunology Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology LPSs Macrophage Activation - drug effects Macrophage Activation - immunology macrophages Macrophages - immunology Membrane Glycoproteins - immunology Mice Mice, Inbred BALB C MR mannose receptor Mϕ macrophages PP proteose peptone Receptors, Cell Surface - immunology Salmonella - immunology Salmonella minnesota Salmonella typhimurium Signal Transduction - drug effects Signal Transduction - immunology SP-A surfactant protein-A TGC thioglycollate TLR Toll-like receptor TNF tumor necrosis factor Toll-Like Receptor 4 - immunology
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