Ammonia pulses and metabolic oscillations guide yeast colony development
On solid substrate, growing yeast colonies alternately acidify and alkalinize the medium. Using morphological, cytochemical, genetic, and DNA microarray approaches, we characterized six temporal steps in the "acid-to-alkali" colony transition. This transition is connected with the producti...
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| Veröffentlicht in: | Molecular biology of the cell 2002-11, Vol.13 (11), p.3901-3914 |
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| container_title | Molecular biology of the cell |
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| creator | Palková, Zdena Devaux, Frédéric Icicová, Markéta Mináriková, Lucie Le Crom, Stéphane Jacq, Claude |
| description | On solid substrate, growing yeast colonies alternately acidify and alkalinize the medium. Using morphological, cytochemical, genetic, and DNA microarray approaches, we characterized six temporal steps in the "acid-to-alkali" colony transition. This transition is connected with the production of volatile ammonia acting as starvation signal between colonies. We present evidence that the three membrane proteins Ato1p, Ato2p, and Ato3p, members of the YaaH family, are involved in ammonia production in Saccharomyces cerevisiae colonies. The acid-to-alkali transition is connected with decrease of mitochondrial oxidative catabolism and by peroxisome activation, which in parallel with activation of biosynthetic pathways contribute to decrease the general stress level in colonies. These metabolic features characterize a novel survival strategy used by yeast under starvation conditions prevalent in nature. |
| doi_str_mv | 10.1091/mbc.E01-12-0149 |
| format | Article |
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Using morphological, cytochemical, genetic, and DNA microarray approaches, we characterized six temporal steps in the "acid-to-alkali" colony transition. This transition is connected with the production of volatile ammonia acting as starvation signal between colonies. We present evidence that the three membrane proteins Ato1p, Ato2p, and Ato3p, members of the YaaH family, are involved in ammonia production in Saccharomyces cerevisiae colonies. The acid-to-alkali transition is connected with decrease of mitochondrial oxidative catabolism and by peroxisome activation, which in parallel with activation of biosynthetic pathways contribute to decrease the general stress level in colonies. 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Using morphological, cytochemical, genetic, and DNA microarray approaches, we characterized six temporal steps in the "acid-to-alkali" colony transition. This transition is connected with the production of volatile ammonia acting as starvation signal between colonies. We present evidence that the three membrane proteins Ato1p, Ato2p, and Ato3p, members of the YaaH family, are involved in ammonia production in Saccharomyces cerevisiae colonies. The acid-to-alkali transition is connected with decrease of mitochondrial oxidative catabolism and by peroxisome activation, which in parallel with activation of biosynthetic pathways contribute to decrease the general stress level in colonies. These metabolic features characterize a novel survival strategy used by yeast under starvation conditions prevalent in nature.</description><subject>Amino Acid Sequence</subject><subject>Amino Acids</subject><subject>Amino Acids - metabolism</subject><subject>Ammonia</subject><subject>Ammonia - metabolism</subject><subject>Biochemistry, Molecular Biology</subject><subject>Energy Metabolism</subject><subject>Fatty Acids</subject><subject>Fatty Acids - metabolism</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Genomics</subject><subject>Hydrogen-Ion Concentration</subject><subject>Life Sciences</subject><subject>Membrane Transport Proteins</subject><subject>Membrane Transport Proteins - chemistry</subject><subject>Membrane Transport Proteins - classification</subject><subject>Membrane Transport Proteins - genetics</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Models, Biological</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oxidative Phosphorylation</subject><subject>Peroxisomes</subject><subject>Peroxisomes - metabolism</subject><subject>Phylogeny</subject><subject>Quantitative Methods</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae - physiology</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>Saccharomyces cerevisiae Proteins - chemistry</subject><subject>Saccharomyces cerevisiae Proteins - metabolism</subject><subject>Sequence Alignment</subject><issn>1059-1524</issn><issn>1939-4586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxa2qqHy0595QTpV6CHj8lfjAYYUoi7QSFzhbjjMGV0m8xMlK-9_j1a5K4cLJluf35s34EfIT6AVQDZd94y5uKJTASgpCfyEnoLkuhazV13ynUpcgmTgmpyn9pRkRqvpGjoEJpmsuTshy0fdxCLZYz13CVNihLXqcbBO74IqYXOg6O4U4pOJpDi0WW7RpKlzs4rAtWtxgF9c9DtN3cuRtbvHjcJ6Rxz83D9fLcnV_e3e9WJVO6moqG-2FpdJLD6AqpWqqWqS1dN4h98xJjppjVQvOZONQOe6tqKiwmvmGM8HPyNW-73puemxdth5tZ9Zj6O24NdEG874yhGfzFDcGOFeUZf3vvf75g2q5WJndG2V1pTO6gcz-OniN8WXGNJk-JIf5RwaMczIVUxUFzj4FQau8ktiBl3vQjTGlEf2_EYCaXaImJ2qQggFmdolmxfn_-77xhwj5K_4Vnbo</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>Palková, Zdena</creator><creator>Devaux, Frédéric</creator><creator>Icicová, Markéta</creator><creator>Mináriková, Lucie</creator><creator>Le Crom, Stéphane</creator><creator>Jacq, Claude</creator><general>American Society for Cell Biology</general><general>The American Society for Cell Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0039-9096</orcidid><orcidid>https://orcid.org/0000-0002-0534-7797</orcidid></search><sort><creationdate>200211</creationdate><title>Ammonia pulses and metabolic oscillations guide yeast colony development</title><author>Palková, Zdena ; Devaux, Frédéric ; Icicová, Markéta ; Mináriková, Lucie ; Le Crom, Stéphane ; Jacq, Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c597t-b9f4a05f5f116766806de085cfce3f2c53e93e784325bce6c3fa4704a92fb3243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Sequence</topic><topic>Amino Acids</topic><topic>Amino Acids - metabolism</topic><topic>Ammonia</topic><topic>Ammonia - metabolism</topic><topic>Biochemistry, Molecular Biology</topic><topic>Energy Metabolism</topic><topic>Fatty Acids</topic><topic>Fatty Acids - metabolism</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Genomics</topic><topic>Hydrogen-Ion Concentration</topic><topic>Life Sciences</topic><topic>Membrane Transport Proteins</topic><topic>Membrane Transport Proteins - chemistry</topic><topic>Membrane Transport Proteins - classification</topic><topic>Membrane Transport Proteins - genetics</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>Models, Biological</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oxidative Phosphorylation</topic><topic>Peroxisomes</topic><topic>Peroxisomes - metabolism</topic><topic>Phylogeny</topic><topic>Quantitative Methods</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae - physiology</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>Saccharomyces cerevisiae Proteins - chemistry</topic><topic>Saccharomyces cerevisiae Proteins - metabolism</topic><topic>Sequence Alignment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palková, Zdena</creatorcontrib><creatorcontrib>Devaux, Frédéric</creatorcontrib><creatorcontrib>Icicová, Markéta</creatorcontrib><creatorcontrib>Mináriková, Lucie</creatorcontrib><creatorcontrib>Le Crom, Stéphane</creatorcontrib><creatorcontrib>Jacq, Claude</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular biology of the cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palková, Zdena</au><au>Devaux, Frédéric</au><au>Icicová, Markéta</au><au>Mináriková, Lucie</au><au>Le Crom, Stéphane</au><au>Jacq, Claude</au><au>Devreotes, Peter N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ammonia pulses and metabolic oscillations guide yeast colony development</atitle><jtitle>Molecular biology of the cell</jtitle><addtitle>Mol Biol Cell</addtitle><date>2002-11</date><risdate>2002</risdate><volume>13</volume><issue>11</issue><spage>3901</spage><epage>3914</epage><pages>3901-3914</pages><issn>1059-1524</issn><eissn>1939-4586</eissn><abstract>On solid substrate, growing yeast colonies alternately acidify and alkalinize the medium. Using morphological, cytochemical, genetic, and DNA microarray approaches, we characterized six temporal steps in the "acid-to-alkali" colony transition. This transition is connected with the production of volatile ammonia acting as starvation signal between colonies. We present evidence that the three membrane proteins Ato1p, Ato2p, and Ato3p, members of the YaaH family, are involved in ammonia production in Saccharomyces cerevisiae colonies. The acid-to-alkali transition is connected with decrease of mitochondrial oxidative catabolism and by peroxisome activation, which in parallel with activation of biosynthetic pathways contribute to decrease the general stress level in colonies. 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| subjects | Amino Acid Sequence Amino Acids Amino Acids - metabolism Ammonia Ammonia - metabolism Biochemistry, Molecular Biology Energy Metabolism Fatty Acids Fatty Acids - metabolism Gene Expression Profiling Gene Expression Regulation, Fungal Genomics Hydrogen-Ion Concentration Life Sciences Membrane Transport Proteins Membrane Transport Proteins - chemistry Membrane Transport Proteins - classification Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Models, Biological Molecular Sequence Data Oligonucleotide Array Sequence Analysis Oxidative Phosphorylation Peroxisomes Peroxisomes - metabolism Phylogeny Quantitative Methods Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment |
| title | Ammonia pulses and metabolic oscillations guide yeast colony development |
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