Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt
The northeast Nile Delta region exhibits a high incidence of early-onset pancreatic cancer. It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic studies have suggested that cadmium, a prevalent pollutant in the northeast Nile Delta region, plays a...
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| Veröffentlicht in: | Environmental health perspectives 2006-01, Vol.114 (1), p.113-119 |
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| creator | Kriegel, Alison M. Soliman, Amr S. Zhang, Qing El-Ghawalby, Nabih Ezzat, Farouk Soultan, Ahmed Abdel-Wahab, Mohamed Fathy, Omar Ebidi, Gamal Bassiouni, Nadia Hamilton, Stanley R. Abbruzzese, James L. Lacey, Michelle R. Blake, Diane A. |
| description | The northeast Nile Delta region exhibits a high incidence of early-onset pancreatic cancer. It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic studies have suggested that cadmium, a prevalent pollutant in the northeast Nile Delta region, plays a role in the development of pancreatic cancer. Objective: We aimed to assess serum cadmium levels as markers of exposure in pancreatic cancer patients and noncancer comparison subjects from the same region in Egypt. Design and Participants: We assessed serum cadmium levels of 31 newly diagnosed pancreatic cancer patients and 52 hospital comparison subjects from Mansoura, Egypt. Evaluation/Measurements: Serum cadmium levels were measured using a novel immunoassay procedure. Results: We found a significant difference between the mean serum cadmium levels in patients versus comparison subjects (mean ± SD, 11.1 ± 7.7 ng/mL vs. 7.1 ± 5.0 ng/mL, respectively; p = 0.012) but not in age, sex, residence, occupation, or smoking status. The odds ratio (OR) for pancreatic cancer risk was significant for serum cadmium level [OR = 1.12; 95% confidence interval (CI), 1.04-1.23; p = 0.0089] and farming (OR = 3.25; 95% CI, 1.03-11.64; p = 0.0475) but not for age, sex, residence, or smoking status. Conclusions: The results from this pilot study suggest that pancreatic cancer in the East Nile Delta region is significantly associated with high levels of serum cadmium and farming. Relevance to Clinical Practice/Public Health: Future studies should further investigate the etiologic relationship between cadmium exposure and pancreatic carcinogenesis in cadmium-exposed populations. |
| doi_str_mv | 10.1289/ehp.8035 |
| format | Article |
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It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic studies have suggested that cadmium, a prevalent pollutant in the northeast Nile Delta region, plays a role in the development of pancreatic cancer. Objective: We aimed to assess serum cadmium levels as markers of exposure in pancreatic cancer patients and noncancer comparison subjects from the same region in Egypt. Design and Participants: We assessed serum cadmium levels of 31 newly diagnosed pancreatic cancer patients and 52 hospital comparison subjects from Mansoura, Egypt. Evaluation/Measurements: Serum cadmium levels were measured using a novel immunoassay procedure. Results: We found a significant difference between the mean serum cadmium levels in patients versus comparison subjects (mean ± SD, 11.1 ± 7.7 ng/mL vs. 7.1 ± 5.0 ng/mL, respectively; p = 0.012) but not in age, sex, residence, occupation, or smoking status. The odds ratio (OR) for pancreatic cancer risk was significant for serum cadmium level [OR = 1.12; 95% confidence interval (CI), 1.04-1.23; p = 0.0089] and farming (OR = 3.25; 95% CI, 1.03-11.64; p = 0.0475) but not for age, sex, residence, or smoking status. Conclusions: The results from this pilot study suggest that pancreatic cancer in the East Nile Delta region is significantly associated with high levels of serum cadmium and farming. Relevance to Clinical Practice/Public Health: Future studies should further investigate the etiologic relationship between cadmium exposure and pancreatic carcinogenesis in cadmium-exposed populations.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.8035</identifier><identifier>PMID: 16393667</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Adult ; Age ; Aged ; Agriculture ; Antibodies ; Blood ; Cadmium ; Cadmium - blood ; Cancer ; Carcinogenesis ; Carcinogens ; Case-Control Studies ; Cigarette smoking ; Confidence intervals ; Deltas ; Egypt - epidemiology ; Environmental health ; Environmental Medicine ; Environmental Pollutants - blood ; Epidemiology ; Farming ; Female ; Health ; Health risks ; Hospitals ; Humans ; Immunoassay ; Male ; Markers ; Middle Aged ; Northeast ; Occupation ; Pancreas ; Pancreatic cancer ; Pancreatic neoplasms ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - etiology ; Patients ; Pollution levels ; Populations ; Predisposing factors ; Public health ; Risk ; Risk Factors ; Risk factors (Health) ; Serums ; Sex ; Smoking ; Tobacco smoking</subject><ispartof>Environmental health perspectives, 2006-01, Vol.114 (1), p.113-119</ispartof><rights>COPYRIGHT 2006 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Jan 2006</rights><rights>2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c719t-e1d5e5351041a49fb2e7d6f60bcf429cf8be8df47c138ca5e3cc5dc74a589aa33</citedby><cites>FETCH-LOGICAL-c719t-e1d5e5351041a49fb2e7d6f60bcf429cf8be8df47c138ca5e3cc5dc74a589aa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3436636$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3436636$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16393667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kriegel, Alison M.</creatorcontrib><creatorcontrib>Soliman, Amr S.</creatorcontrib><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>El-Ghawalby, Nabih</creatorcontrib><creatorcontrib>Ezzat, Farouk</creatorcontrib><creatorcontrib>Soultan, Ahmed</creatorcontrib><creatorcontrib>Abdel-Wahab, Mohamed</creatorcontrib><creatorcontrib>Fathy, Omar</creatorcontrib><creatorcontrib>Ebidi, Gamal</creatorcontrib><creatorcontrib>Bassiouni, Nadia</creatorcontrib><creatorcontrib>Hamilton, Stanley R.</creatorcontrib><creatorcontrib>Abbruzzese, James L.</creatorcontrib><creatorcontrib>Lacey, Michelle R.</creatorcontrib><creatorcontrib>Blake, Diane A.</creatorcontrib><title>Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>The northeast Nile Delta region exhibits a high incidence of early-onset pancreatic cancer. It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic studies have suggested that cadmium, a prevalent pollutant in the northeast Nile Delta region, plays a role in the development of pancreatic cancer. Objective: We aimed to assess serum cadmium levels as markers of exposure in pancreatic cancer patients and noncancer comparison subjects from the same region in Egypt. Design and Participants: We assessed serum cadmium levels of 31 newly diagnosed pancreatic cancer patients and 52 hospital comparison subjects from Mansoura, Egypt. Evaluation/Measurements: Serum cadmium levels were measured using a novel immunoassay procedure. Results: We found a significant difference between the mean serum cadmium levels in patients versus comparison subjects (mean ± SD, 11.1 ± 7.7 ng/mL vs. 7.1 ± 5.0 ng/mL, respectively; p = 0.012) but not in age, sex, residence, occupation, or smoking status. The odds ratio (OR) for pancreatic cancer risk was significant for serum cadmium level [OR = 1.12; 95% confidence interval (CI), 1.04-1.23; p = 0.0089] and farming (OR = 3.25; 95% CI, 1.03-11.64; p = 0.0475) but not for age, sex, residence, or smoking status. Conclusions: The results from this pilot study suggest that pancreatic cancer in the East Nile Delta region is significantly associated with high levels of serum cadmium and farming. Relevance to Clinical Practice/Public Health: Future studies should further investigate the etiologic relationship between cadmium exposure and pancreatic carcinogenesis in cadmium-exposed populations.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Agriculture</subject><subject>Antibodies</subject><subject>Blood</subject><subject>Cadmium</subject><subject>Cadmium - blood</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Case-Control Studies</subject><subject>Cigarette smoking</subject><subject>Confidence intervals</subject><subject>Deltas</subject><subject>Egypt - epidemiology</subject><subject>Environmental health</subject><subject>Environmental Medicine</subject><subject>Environmental Pollutants - blood</subject><subject>Epidemiology</subject><subject>Farming</subject><subject>Female</subject><subject>Health</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Male</subject><subject>Markers</subject><subject>Middle Aged</subject><subject>Northeast</subject><subject>Occupation</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic neoplasms</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - etiology</subject><subject>Patients</subject><subject>Pollution levels</subject><subject>Populations</subject><subject>Predisposing factors</subject><subject>Public health</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Risk factors (Health)</subject><subject>Serums</subject><subject>Sex</subject><subject>Smoking</subject><subject>Tobacco smoking</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN081rFDEUAPBBFLtWwT9AZOih6mHWfGfmIpR11cJipVUvHkI282Y2ZWayJpli_3uz7FK7UrTkEMj75ZGP97LsOUZTTMrqLazW0xJR_iCbYM5JUVWEPcwmCFW4EFLwg-xJCJcIIVwK8Tg7wIJWVAg5yX5cgB_7fKbr3qZ5AVfQhdwO-Rc9GA86WpOCgwGfVqKFIYa88a7P4wryuQ4x_2w7yN9DF3V-Dq11Q-6afN5er-PT7FGjuwDPdvNh9u3D_OvsU7E4-3g6O1kURuIqFoBrDpxyjBjWrGqWBGQtGoGWpmGkMk25hLJumDSYlkZzoMbw2kimeVlpTelh9m6bdz0ue6hNOqTXnVp722t_rZy2aj8y2JVq3ZXClBIheErwapfAu58jhKh6Gwx0nR7AjUFJRplEjGzk8T8lwbQiUtL_QiwJZYzfAzIpaHqaBI_-gpdu9EN6WEUIEbQkbJOt2KJWd6Ds0Lh0YdPCAOneboAmfZY6wYwgXqZiSH56h0-jht6aOze82duQTIRfsdVjCOr04vz-9uz7vj2-ZVegu7gKrhtjKqiwD19vofEuBA_NzT9jpDbNoFIzqE0zJPrydl38gbvqT-DFFlyG6PxNnLIUpYL-BpkrCg8</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Kriegel, Alison M.</creator><creator>Soliman, Amr S.</creator><creator>Zhang, Qing</creator><creator>El-Ghawalby, Nabih</creator><creator>Ezzat, Farouk</creator><creator>Soultan, Ahmed</creator><creator>Abdel-Wahab, Mohamed</creator><creator>Fathy, Omar</creator><creator>Ebidi, Gamal</creator><creator>Bassiouni, Nadia</creator><creator>Hamilton, Stanley R.</creator><creator>Abbruzzese, James L.</creator><creator>Lacey, Michelle R.</creator><creator>Blake, Diane A.</creator><general>National Institute of Environmental Health Sciences. 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Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt</title><author>Kriegel, Alison M. ; Soliman, Amr S. ; Zhang, Qing ; El-Ghawalby, Nabih ; Ezzat, Farouk ; Soultan, Ahmed ; Abdel-Wahab, Mohamed ; Fathy, Omar ; Ebidi, Gamal ; Bassiouni, Nadia ; Hamilton, Stanley R. ; Abbruzzese, James L. ; Lacey, Michelle R. ; Blake, Diane A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c719t-e1d5e5351041a49fb2e7d6f60bcf429cf8be8df47c138ca5e3cc5dc74a589aa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Agriculture</topic><topic>Antibodies</topic><topic>Blood</topic><topic>Cadmium</topic><topic>Cadmium - blood</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Case-Control Studies</topic><topic>Cigarette smoking</topic><topic>Confidence 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R.</au><au>Abbruzzese, James L.</au><au>Lacey, Michelle R.</au><au>Blake, Diane A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>114</volume><issue>1</issue><spage>113</spage><epage>119</epage><pages>113-119</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>The northeast Nile Delta region exhibits a high incidence of early-onset pancreatic cancer. It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic studies have suggested that cadmium, a prevalent pollutant in the northeast Nile Delta region, plays a role in the development of pancreatic cancer. Objective: We aimed to assess serum cadmium levels as markers of exposure in pancreatic cancer patients and noncancer comparison subjects from the same region in Egypt. Design and Participants: We assessed serum cadmium levels of 31 newly diagnosed pancreatic cancer patients and 52 hospital comparison subjects from Mansoura, Egypt. Evaluation/Measurements: Serum cadmium levels were measured using a novel immunoassay procedure. Results: We found a significant difference between the mean serum cadmium levels in patients versus comparison subjects (mean ± SD, 11.1 ± 7.7 ng/mL vs. 7.1 ± 5.0 ng/mL, respectively; p = 0.012) but not in age, sex, residence, occupation, or smoking status. The odds ratio (OR) for pancreatic cancer risk was significant for serum cadmium level [OR = 1.12; 95% confidence interval (CI), 1.04-1.23; p = 0.0089] and farming (OR = 3.25; 95% CI, 1.03-11.64; p = 0.0475) but not for age, sex, residence, or smoking status. Conclusions: The results from this pilot study suggest that pancreatic cancer in the East Nile Delta region is significantly associated with high levels of serum cadmium and farming. Relevance to Clinical Practice/Public Health: Future studies should further investigate the etiologic relationship between cadmium exposure and pancreatic carcinogenesis in cadmium-exposed populations.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>16393667</pmid><doi>10.1289/ehp.8035</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental health perspectives, 2006-01, Vol.114 (1), p.113-119 |
| issn | 0091-6765 1552-9924 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Age Aged Agriculture Antibodies Blood Cadmium Cadmium - blood Cancer Carcinogenesis Carcinogens Case-Control Studies Cigarette smoking Confidence intervals Deltas Egypt - epidemiology Environmental health Environmental Medicine Environmental Pollutants - blood Epidemiology Farming Female Health Health risks Hospitals Humans Immunoassay Male Markers Middle Aged Northeast Occupation Pancreas Pancreatic cancer Pancreatic neoplasms Pancreatic Neoplasms - blood Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - etiology Patients Pollution levels Populations Predisposing factors Public health Risk Risk Factors Risk factors (Health) Serums Sex Smoking Tobacco smoking |
| title | Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T21%3A54%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20Cadmium%20Levels%20in%20Pancreatic%20Cancer%20Patients%20from%20the%20East%20Nile%20Delta%20Region%20of%20Egypt&rft.jtitle=Environmental%20health%20perspectives&rft.au=Kriegel,%20Alison%20M.&rft.date=2006-01-01&rft.volume=114&rft.issue=1&rft.spage=113&rft.epage=119&rft.pages=113-119&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.8035&rft_dat=%3Cgale_pubme%3EA142058018%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222638243&rft_id=info:pmid/16393667&rft_galeid=A142058018&rft_jstor_id=3436636&rfr_iscdi=true |