An electrical description of the motoneurone, and its application to the analysis of synaptic potentials
1. The Rall model of the motoneurone, which consists of a lumped resistance and capacitance, representing the soma, in parallel with a distributed resistanceâcapacitance network of finite length, representing the equivalent dendritic cable, has been used to investigate the effects of varying elect...
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| Veröffentlicht in: | The Journal of physiology 1971-06, Vol.215 (2), p.321-352 |
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| container_title | The Journal of physiology |
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| creator | Jack, J. J. B. Redman, S. J. |
| description | 1. The Rall model of the motoneurone, which consists of a lumped resistance and capacitance, representing the soma, in parallel
with a distributed resistanceâcapacitance network of finite length, representing the equivalent dendritic cable, has been
used to investigate the effects of varying electrical and geometrical parameters on the time course of transients generated
at the model soma.
2. An analytical solution has been obtained for the voltage at the model soma, following a brief current injection at any
point on the dendritic cable, in terms of the dendritic to soma conductance ratio, the electrotonic length of the cable, the
membrane time constant, and the electrotonic distance between the point of current injection and the soma. This solution has
been used to study the response at the soma to currents with a smooth time course, and to brief rectangular current pulses.
Computations of these voltage transients are given to illustrate the effect of the above parameters on voltage time course.
3. A method for determining the membrane time constant, the dendritic to soma conductance ratio, and the electrotonic length
of the dendritic cable, is described. The method involves measurements from the decay time course of the transient at the
soma following a brief current pulse being applied at the soma.
4. A method is described whereby the time course of a synaptic potential, assumed to be generated by synaptic knobs located
exclusively at the soma, may be used to determine the motoneurone parameters, and a parameter describing the time course of
current injection.
5. A method for estimating the distance between soma and origin of a non-somatic synaptic potential, once the parameters of
the motoneurone are known, is described. |
| doi_str_mv | 10.1113/jphysiol.1971.sp009473 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1331887</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1694972810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5331-c37b572a9903ee297b485be799f9b289a93c5d8e95eb62517e62063fe84f20e53</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0EKkvhJ4B8Ag5k8UccxxekUvGpSnAoZ8vxThpX3jjYXqr8e5xmW8EFcfFInud9Z0YvQi8o2VJK-dvraZiTC35LlaTbNBGiaskfoA2tG1VJqfhDtCGEsYpLQR-jJyldE0I5UeoEnQhaC8nYBg1nIwYPNkdnjcc7SDa6Kbsw4tDjPADehxxGOMTyvMFm3GGXEzbT5IvglsvhljOj8WWjtOjSPJpiYvEUMozZGZ-eokd9KfDsWE_Rj48fLs8_VxffPn05P7uorOCcVpbLrmxmlCIcgCnZ1a3oQCrVq461yihuxa4FJaBrmKASGkYa3kNb94yA4Kfo3eo7Hbo97GwZH43XU3R7E2cdjNN_d0Y36KvwS9Myvm1lMXh5NIjh5wFS1nuXLHhvRgiHpFvK2lrWy6TX_wRpo2olWUtJQZsVtTGkFKG_34cSvcSp7-LUS5z6Ls4ifP7nNfeyY36l_37t3zgP83-66suv35cPRgXjjBaTV6vJ4K6GGxdBr7IUrIM868JpphfyN1S4w54</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1694972810</pqid></control><display><type>article</type><title>An electrical description of the motoneurone, and its application to the analysis of synaptic potentials</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Jack, J. J. B. ; Redman, S. J.</creator><creatorcontrib>Jack, J. J. B. ; Redman, S. J.</creatorcontrib><description>1. The Rall model of the motoneurone, which consists of a lumped resistance and capacitance, representing the soma, in parallel
with a distributed resistanceâcapacitance network of finite length, representing the equivalent dendritic cable, has been
used to investigate the effects of varying electrical and geometrical parameters on the time course of transients generated
at the model soma.
2. An analytical solution has been obtained for the voltage at the model soma, following a brief current injection at any
point on the dendritic cable, in terms of the dendritic to soma conductance ratio, the electrotonic length of the cable, the
membrane time constant, and the electrotonic distance between the point of current injection and the soma. This solution has
been used to study the response at the soma to currents with a smooth time course, and to brief rectangular current pulses.
Computations of these voltage transients are given to illustrate the effect of the above parameters on voltage time course.
3. A method for determining the membrane time constant, the dendritic to soma conductance ratio, and the electrotonic length
of the dendritic cable, is described. The method involves measurements from the decay time course of the transient at the
soma following a brief current pulse being applied at the soma.
4. A method is described whereby the time course of a synaptic potential, assumed to be generated by synaptic knobs located
exclusively at the soma, may be used to determine the motoneurone parameters, and a parameter describing the time course of
current injection.
5. A method for estimating the distance between soma and origin of a non-somatic synaptic potential, once the parameters of
the motoneurone are known, is described.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1971.sp009473</identifier><identifier>PMID: 5145722</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Computers ; Dendrites - physiology ; Electric Conductivity ; Electric Stimulation ; Electrophysiology ; Models, Neurological ; Motor Neurons - physiology ; Synapses - physiology ; Time Factors</subject><ispartof>The Journal of physiology, 1971-06, Vol.215 (2), p.321-352</ispartof><rights>1971 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5331-c37b572a9903ee297b485be799f9b289a93c5d8e95eb62517e62063fe84f20e53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331887/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331887/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,1412,27905,27906,45555,45556,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5145722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jack, J. J. B.</creatorcontrib><creatorcontrib>Redman, S. J.</creatorcontrib><title>An electrical description of the motoneurone, and its application to the analysis of synaptic potentials</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. The Rall model of the motoneurone, which consists of a lumped resistance and capacitance, representing the soma, in parallel
with a distributed resistanceâcapacitance network of finite length, representing the equivalent dendritic cable, has been
used to investigate the effects of varying electrical and geometrical parameters on the time course of transients generated
at the model soma.
2. An analytical solution has been obtained for the voltage at the model soma, following a brief current injection at any
point on the dendritic cable, in terms of the dendritic to soma conductance ratio, the electrotonic length of the cable, the
membrane time constant, and the electrotonic distance between the point of current injection and the soma. This solution has
been used to study the response at the soma to currents with a smooth time course, and to brief rectangular current pulses.
Computations of these voltage transients are given to illustrate the effect of the above parameters on voltage time course.
3. A method for determining the membrane time constant, the dendritic to soma conductance ratio, and the electrotonic length
of the dendritic cable, is described. The method involves measurements from the decay time course of the transient at the
soma following a brief current pulse being applied at the soma.
4. A method is described whereby the time course of a synaptic potential, assumed to be generated by synaptic knobs located
exclusively at the soma, may be used to determine the motoneurone parameters, and a parameter describing the time course of
current injection.
5. A method for estimating the distance between soma and origin of a non-somatic synaptic potential, once the parameters of
the motoneurone are known, is described.</description><subject>Computers</subject><subject>Dendrites - physiology</subject><subject>Electric Conductivity</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Models, Neurological</subject><subject>Motor Neurons - physiology</subject><subject>Synapses - physiology</subject><subject>Time Factors</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EKkvhJ4B8Ag5k8UccxxekUvGpSnAoZ8vxThpX3jjYXqr8e5xmW8EFcfFInud9Z0YvQi8o2VJK-dvraZiTC35LlaTbNBGiaskfoA2tG1VJqfhDtCGEsYpLQR-jJyldE0I5UeoEnQhaC8nYBg1nIwYPNkdnjcc7SDa6Kbsw4tDjPADehxxGOMTyvMFm3GGXEzbT5IvglsvhljOj8WWjtOjSPJpiYvEUMozZGZ-eokd9KfDsWE_Rj48fLs8_VxffPn05P7uorOCcVpbLrmxmlCIcgCnZ1a3oQCrVq461yihuxa4FJaBrmKASGkYa3kNb94yA4Kfo3eo7Hbo97GwZH43XU3R7E2cdjNN_d0Y36KvwS9Myvm1lMXh5NIjh5wFS1nuXLHhvRgiHpFvK2lrWy6TX_wRpo2olWUtJQZsVtTGkFKG_34cSvcSp7-LUS5z6Ls4ifP7nNfeyY36l_37t3zgP83-66suv35cPRgXjjBaTV6vJ4K6GGxdBr7IUrIM868JpphfyN1S4w54</recordid><startdate>19710601</startdate><enddate>19710601</enddate><creator>Jack, J. J. B.</creator><creator>Redman, S. J.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19710601</creationdate><title>An electrical description of the motoneurone, and its application to the analysis of synaptic potentials</title><author>Jack, J. J. B. ; Redman, S. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5331-c37b572a9903ee297b485be799f9b289a93c5d8e95eb62517e62063fe84f20e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Computers</topic><topic>Dendrites - physiology</topic><topic>Electric Conductivity</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Models, Neurological</topic><topic>Motor Neurons - physiology</topic><topic>Synapses - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jack, J. J. B.</creatorcontrib><creatorcontrib>Redman, S. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jack, J. J. B.</au><au>Redman, S. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An electrical description of the motoneurone, and its application to the analysis of synaptic potentials</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1971-06-01</date><risdate>1971</risdate><volume>215</volume><issue>2</issue><spage>321</spage><epage>352</epage><pages>321-352</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. The Rall model of the motoneurone, which consists of a lumped resistance and capacitance, representing the soma, in parallel
with a distributed resistanceâcapacitance network of finite length, representing the equivalent dendritic cable, has been
used to investigate the effects of varying electrical and geometrical parameters on the time course of transients generated
at the model soma.
2. An analytical solution has been obtained for the voltage at the model soma, following a brief current injection at any
point on the dendritic cable, in terms of the dendritic to soma conductance ratio, the electrotonic length of the cable, the
membrane time constant, and the electrotonic distance between the point of current injection and the soma. This solution has
been used to study the response at the soma to currents with a smooth time course, and to brief rectangular current pulses.
Computations of these voltage transients are given to illustrate the effect of the above parameters on voltage time course.
3. A method for determining the membrane time constant, the dendritic to soma conductance ratio, and the electrotonic length
of the dendritic cable, is described. The method involves measurements from the decay time course of the transient at the
soma following a brief current pulse being applied at the soma.
4. A method is described whereby the time course of a synaptic potential, assumed to be generated by synaptic knobs located
exclusively at the soma, may be used to determine the motoneurone parameters, and a parameter describing the time course of
current injection.
5. A method for estimating the distance between soma and origin of a non-somatic synaptic potential, once the parameters of
the motoneurone are known, is described.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>5145722</pmid><doi>10.1113/jphysiol.1971.sp009473</doi><tpages>32</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of physiology, 1971-06, Vol.215 (2), p.321-352 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1331887 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Computers Dendrites - physiology Electric Conductivity Electric Stimulation Electrophysiology Models, Neurological Motor Neurons - physiology Synapses - physiology Time Factors |
| title | An electrical description of the motoneurone, and its application to the analysis of synaptic potentials |
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