Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog
1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a low concentration of calcium and a high concentration of magnesium. 2. The muscle was subsequently subjected to `cholinesterase staining', and the area of the individual en...
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| Veröffentlicht in: | The Journal of physiology 1971-03, Vol.213 (3), p.545-556 |
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| container_title | The Journal of physiology |
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| creator | Kuno, M. Turkanis, S. A. Weakly, J. N. |
| description | 1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a
low concentration of calcium and a high concentration of magnesium.
2. The muscle was subsequently subjected to `cholinesterase staining', and the area of the individual end-plates, studied
with intracellular electrodes, was measured.
3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.
4. The mean quantum content ( m ) showed a positive correlation with the size of end-plates.
5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.
6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings. |
| doi_str_mv | 10.1113/jphysiol.1971.sp009399 |
| format | Article |
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low concentration of calcium and a high concentration of magnesium.
2. The muscle was subsequently subjected to `cholinesterase staining', and the area of the individual end-plates, studied
with intracellular electrodes, was measured.
3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.
4. The mean quantum content ( m ) showed a positive correlation with the size of end-plates.
5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.
6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1971.sp009399</identifier><identifier>PMID: 4323933</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Anura ; Calcium - pharmacology ; Cholinesterases ; Electric Stimulation ; Electrophysiology ; In Vitro Techniques ; Magnesium - pharmacology ; Membrane Potentials ; Myofibrils - physiology ; Nerve Endings - anatomy & histology ; Neuromuscular Junction - physiology ; Synaptic Transmission</subject><ispartof>The Journal of physiology, 1971-03, Vol.213 (3), p.545-556</ispartof><rights>1971 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5335-5a62f9629bfec171fe300cbe023c325ba01adc99e0d3d2aab1a8e561eea89dda3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331740/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1331740/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4323933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuno, M.</creatorcontrib><creatorcontrib>Turkanis, S. A.</creatorcontrib><creatorcontrib>Weakly, J. N.</creatorcontrib><title>Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a
low concentration of calcium and a high concentration of magnesium.
2. The muscle was subsequently subjected to `cholinesterase staining', and the area of the individual end-plates, studied
with intracellular electrodes, was measured.
3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.
4. The mean quantum content ( m ) showed a positive correlation with the size of end-plates.
5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.
6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings.</description><subject>Animals</subject><subject>Anura</subject><subject>Calcium - pharmacology</subject><subject>Cholinesterases</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>In Vitro Techniques</subject><subject>Magnesium - pharmacology</subject><subject>Membrane Potentials</subject><subject>Myofibrils - physiology</subject><subject>Nerve Endings - anatomy & histology</subject><subject>Neuromuscular Junction - physiology</subject><subject>Synaptic Transmission</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS1EVZbCRwDlRLlksTNxEl-QYMWfokpwKGfLcSYbrxJ7sZOutp8ep9lWcEGcRpr3e08zeoS8ZnTNGIN3u313DMb1ayZKtg57SgUI8YSsWF6ItCwFPCUrSrMshZKzZ-R5CDtKGVAhzsl5DhkIgBUxG-c99mo0ziY1jgdEm1j0t5iM6AdjVZ8Ec4eJsk0yemXDYMaoJNGEKsT9mIwdRsvk3TAFPfXKJ7vJ6vtE196rrXfbF-SsVX3Al6d5QX5-_nSz-Zpef_9ytflwnWoOwFOuiqwVRSbqFjUrWYtAqa6RZqAh47WiTDVaCKQNNJlSNVMV8oIhqko0jYIL8n7J3U_1gI1GG8_u5d6bQfmjdMrIvxVrOrl1t5IBsDKnMeDNKcC7XxOGUQ4maOx7ZdFNQVZU5HlV8Qi-_SfICpGLKudcRLRYUO1dCB7bx3sYlXOf8qFPOfcpH_qMxld_fvNoOxUY9Y-LfjA9Hv8zVd58-zEvsvgyz-dHLpeQzmy7g_EoF1tw2uB4lJGTIGfyN4YUxiM</recordid><startdate>19710301</startdate><enddate>19710301</enddate><creator>Kuno, M.</creator><creator>Turkanis, S. A.</creator><creator>Weakly, J. N.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19710301</creationdate><title>Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog</title><author>Kuno, M. ; Turkanis, S. A. ; Weakly, J. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5335-5a62f9629bfec171fe300cbe023c325ba01adc99e0d3d2aab1a8e561eea89dda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Anura</topic><topic>Calcium - pharmacology</topic><topic>Cholinesterases</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>In Vitro Techniques</topic><topic>Magnesium - pharmacology</topic><topic>Membrane Potentials</topic><topic>Myofibrils - physiology</topic><topic>Nerve Endings - anatomy & histology</topic><topic>Neuromuscular Junction - physiology</topic><topic>Synaptic Transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuno, M.</creatorcontrib><creatorcontrib>Turkanis, S. A.</creatorcontrib><creatorcontrib>Weakly, J. N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuno, M.</au><au>Turkanis, S. A.</au><au>Weakly, J. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1971-03-01</date><risdate>1971</risdate><volume>213</volume><issue>3</issue><spage>545</spage><epage>556</epage><pages>545-556</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a
low concentration of calcium and a high concentration of magnesium.
2. The muscle was subsequently subjected to `cholinesterase staining', and the area of the individual end-plates, studied
with intracellular electrodes, was measured.
3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.
4. The mean quantum content ( m ) showed a positive correlation with the size of end-plates.
5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.
6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>4323933</pmid><doi>10.1113/jphysiol.1971.sp009399</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1971-03, Vol.213 (3), p.545-556 |
| issn | 0022-3751 1469-7793 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Free E-Journal (出版社公開部分のみ）; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Anura Calcium - pharmacology Cholinesterases Electric Stimulation Electrophysiology In Vitro Techniques Magnesium - pharmacology Membrane Potentials Myofibrils - physiology Nerve Endings - anatomy & histology Neuromuscular Junction - physiology Synaptic Transmission |
| title | Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog |
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