Potassium ion accumulation slows the closing rate of potassium channels in squid axons
Potassium ion accumulation in the periaxonal space between squid axonal membrane and the Schwann cell surrounding the axon slows the rate of potassium channel closing to a degree that is consistent with the effect on channel closing of an equivalent change in the bulk external potassium concentratio...
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| Veröffentlicht in: | Biophysical journal 1986-07, Vol.50 (1), p.197-200 |
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| creator | Clay, J.R. |
| description | Potassium ion accumulation in the periaxonal space between squid axonal membrane and the Schwann cell surrounding the axon slows the rate of potassium channel closing to a degree that is consistent with the effect on channel closing of an equivalent change in the bulk external potassium concentration. The alteration of channel gating is independent of membrane potential, V, for V less than or equal to -60 mV, which suggests that the effect is mediated at a site on the outer surface of the membrane, rather than a site within the channel. |
| doi_str_mv | 10.1016/S0006-3495(86)83452-X |
| format | Article |
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The alteration of channel gating is independent of membrane potential, V, for V less than or equal to -60 mV, which suggests that the effect is mediated at a site on the outer surface of the membrane, rather than a site within the channel.</description><identifier>ISSN: 0006-3495</identifier><identifier>EISSN: 1542-0086</identifier><identifier>DOI: 10.1016/S0006-3495(86)83452-X</identifier><identifier>PMID: 2425857</identifier><identifier>CODEN: BIOJAU</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Axons - physiology ; Biological and medical sciences ; Decapodiformes ; Fundamental and applied biological sciences. Psychology ; Ion Channels - physiology ; Isolated neuron and nerve. 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The alteration of channel gating is independent of membrane potential, V, for V less than or equal to -60 mV, which suggests that the effect is mediated at a site on the outer surface of the membrane, rather than a site within the channel.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>Biological and medical sciences</subject><subject>Decapodiformes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ion Channels - physiology</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Mathematics</subject><subject>Models, Neurological</subject><subject>Potassium - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-3495</issn><issn>1542-0086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModa3-hEIuRPRi2nzP5MYixS8oVPCD3oXsmUw3kkm2yUyt_95sdxn0SgiEcJ73vCfnReiEklNKqDr7SghRDRdavu7Um44LyZrrR2hFpWANIZ16jFYL8hQ9K-UnIZRJQo_QERNMdrJdoR9f0mRL8fOIfYrYAszjHOy0e5SQfhU8bRyGkIqPNzjbyeE04O0igo2N0YWCfeVvZ99je59ieY6eDDYU9-JwH6PvH95_u_jUXF59_Hzx7rIBoenUDAPnxIFrtdJatQI4hbWQmrG2U5Tzdd8R0Yu2taSVmtcDFFT9hrQchLD8GL3d993O69H14OKUbTDb7Eebf5tkvfm3Ev3G3KQ7Qzmrhqw2eHVokNPt7MpkRl_AhWCjS3MxrdKiDqIrKPcg5FRKdsNiQonZBWIeAjG7bZtOmYdAzHXVnfw94aI6JFDrLw91W8CGIdsIvixYV82JUBU732N11-7Ou2wKeBfB9T47mEyf_H8G-QPHK6jY</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>Clay, J.R.</creator><general>Elsevier Inc</general><general>Biophysical Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860701</creationdate><title>Potassium ion accumulation slows the closing rate of potassium channels in squid axons</title><author>Clay, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-ff330ece79699674c31cb45922786133bd804d477a07593593c1c60015a3c44a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Axons - physiology</topic><topic>Biological and medical sciences</topic><topic>Decapodiformes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ion Channels - physiology</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Mathematics</topic><topic>Models, Neurological</topic><topic>Potassium - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clay, J.R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biophysical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clay, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potassium ion accumulation slows the closing rate of potassium channels in squid axons</atitle><jtitle>Biophysical journal</jtitle><addtitle>Biophys J</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>50</volume><issue>1</issue><spage>197</spage><epage>200</epage><pages>197-200</pages><issn>0006-3495</issn><eissn>1542-0086</eissn><coden>BIOJAU</coden><abstract>Potassium ion accumulation in the periaxonal space between squid axonal membrane and the Schwann cell surrounding the axon slows the rate of potassium channel closing to a degree that is consistent with the effect on channel closing of an equivalent change in the bulk external potassium concentration. 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| ispartof | Biophysical journal, 1986-07, Vol.50 (1), p.197-200 |
| issn | 0006-3495 1542-0086 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Axons - physiology Biological and medical sciences Decapodiformes Fundamental and applied biological sciences. Psychology Ion Channels - physiology Isolated neuron and nerve. Neuroglia Mathematics Models, Neurological Potassium - metabolism Vertebrates: nervous system and sense organs |
| title | Potassium ion accumulation slows the closing rate of potassium channels in squid axons |
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