Estimation of intracellular [Ca2+] by nonlinear indicators. A quantitative analysis
When spatial gradients of intracellular free [Ca2+] are present, intracellular calcium indicators that have a nonlinear response to [Ca2+] may yield an estimate of [Ca2+] that differs from the spatial average [Ca2+]. We present two rules that provide (a) general criteria to distinguish those classes...
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| Veröffentlicht in: | Biophysical journal 1985-09, Vol.48 (3), p.533-537 |
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| container_title | Biophysical journal |
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| creator | Yue, D.T. Wier, W.G. |
| description | When spatial gradients of intracellular free [Ca2+] are present, intracellular calcium indicators that have a nonlinear response to [Ca2+] may yield an estimate of [Ca2+] that differs from the spatial average [Ca2+]. We present two rules that provide (a) general criteria to distinguish those classes of indicators that will yield an overestimate of spatial average [Ca2+] from those that will yield an underestimate, and (b) limits on the extent to which spatial average [Ca2+] might be over- or underestimated. These rules are used to interpret quantitatively the aequorin luminescence signals obtained from cardiac ventricular myocardium. |
| doi_str_mv | 10.1016/S0006-3495(85)83810-8 |
| format | Article |
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| ispartof | Biophysical journal, 1985-09, Vol.48 (3), p.533-537 |
| issn | 0006-3495 1542-0086 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Applied sciences Biological and medical sciences Body Fluids - analysis calcium Calcium - analysis Cell structures and functions Cytoskeleton, cytoplasm. Intracellular movements Exact sciences and technology Fundamental and applied biological sciences. Psychology Intracellular Fluid - analysis Mathematics Models, Biological Molecular and cellular biology Myocardium - analysis Other techniques and industries |
| title | Estimation of intracellular [Ca2+] by nonlinear indicators. A quantitative analysis |
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