Block of sodium conductance and gating current in squid giant axons poisoned with quaternary strychnine

Quaternary strychnine blocks sodium channels from the axoplasmic side, probably by insertion into the inner channel mouth. Block is strongly voltage dependent, being more pronounced in depolarized than in resting axons. Using potential steps as a means to modulate the level of block, we investigate...

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Veröffentlicht in:	Biophysical journal 1979-07, Vol.27 (1), p.57-73
Hauptverfasser:	Cahalan, M.D., Almers, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - metabolism Decapodiformes Ion Channels - drug effects Ion Channels - metabolism Mathematics Membrane Potentials - drug effects Models, Biological Sodium - metabolism Sodium - pharmacology Strychnine - pharmacology
Online-Zugang:	Volltext
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