Synthesis and hybridization studies of oligonucleotides containing 1-(2-deoxy-2-α-C-hydroxymethyl-β-d-ribofuranosyl)thymine (2′-α-hm-dT)

We report the first investigation of oligoribonucleotides containing a few 1-(2-deoxy-2-α-C-hydroxymethyl-β-d-ribofuranosyl)thymine units (or 2′-hm-dT, abbreviated in this work as ‘H’). Both the 2′-CH2O-phosphoramidite and 3′-O-phosphoramidite derivatives of H were synthesized and incorporated into...

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Veröffentlicht in:	Nucleic acids research 2005-01, Vol.33 (22), p.7019-7028
Hauptverfasser:	Peng, Chang Geng, Damha, Masad J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular Dichroism Nucleic Acid Conformation Nucleic Acid Denaturation Nucleic Acid Hybridization Oligoribonucleotides - chemical synthesis Oligoribonucleotides - chemistry Organophosphorus Compounds - chemistry RNA - chemistry RNA Stability Temperature Thymidine - analogs & derivatives Thymidine - chemistry
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