Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations

Topoisomerase II (Topo II) inhibitors are cell cycle-specific DNA-damaging agents and often correlate with secondary leukemia with chromosomal translocations involving the mixed-lineage leukemia/myeloid lymphoid leukemia (MLL) gene on chromosome 11 band q23 (11q23). In spite of the clinical importan...

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Veröffentlicht in:	The Journal of clinical investigation 2006-01, Vol.116 (1), p.80-89
Hauptverfasser:	Nakada, Shinichiro, Katsuki, Yoko, Imoto, Issei, Yokoyama, Tetsuji, Nagasawa, Masayuki, Inazawa, Johji, Mizutani, Shuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Ataxia Biomedical research Bone Neoplasms Cell cycle Cell Cycle - physiology Cell Division Cell Line Cell Line, Tumor Chromosome Aberrations - chemically induced Chromosome Banding Chromosomes Chromosomes, Human, Pair 11 Cloning, Molecular DNA damage Etoposide - pharmacology G2 Phase Gene Expression Regulation Gene Expression Regulation, Neoplastic Genes Histone-Lysine N-Methyltransferase Humans Leukemia Myeloid-Lymphoid Leukemia Protein - drug effects Myeloid-Lymphoid Leukemia Protein - genetics Osteosarcoma Translocation, Genetic Tumorigenesis Tumors
Online-Zugang:	Volltext
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