The imprinting mechanism of the Prader-Willi/Angelman regional control center

The 2 Mb domain on chromosome 15q11–q13 that carries the imprinted genes involved in Prader–Willi (PWS) and Angelman (AS) syndromes is under the control of an imprinting center comprising two regulatory regions, the PWS‐SRO located around the SNRPN promoter and the AS‐SRO located 35 kb upstream. Her...

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Veröffentlicht in:	The EMBO journal 2002-11, Vol.21 (21), p.5807-5814
Hauptverfasser:	Perk, Jonathan, Makedonski, Kirill, Lande, Laura, Cedar, Howard, Razin, Aharon, Shemer, Ruth
Format:	Artikel
Sprache:	eng
Schlagworte:	Angelman regional control center Base Sequence Chromosomes, Human, Pair 15 Deoxyribonucleic acid DNA DNA methylation DNA Primers DNase sensitivity EMBO09 EMBO24 Genomic Imprinting histone modification Humans Prader-Willi Prader-Willi Syndrome - genetics
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