plo1+ regulates gene transcription at the M-G1 interval during the fission yeast mitotic cell cycle
The regulation of gene expression plays an important part in cell cycle controls. We describe the molecular machinery that co‐ordinates gene transcription at the M–G 1 interval during the fission yeast mitotic cell cycle. A sequence is identified in the cdc15 + promoter that we call a PCB ( p ombe c...
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| Veröffentlicht in: | The EMBO journal 2002-11, Vol.21 (21), p.5745-5755 |
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| creator | Anderson, Mark Ng, Szu Shien Marchesi, Vanessa MacIver, Fiona H. Stevens, Frances E. Riddell, Tracy Glover, David M. Hagan, Iain M. McInerny, Christopher J. |
| description | The regulation of gene expression plays an important part in cell cycle controls. We describe the molecular machinery that co‐ordinates gene transcription at the M–G
1
interval during the fission yeast mitotic cell cycle. A sequence is identified in the
cdc15
+
promoter that we call a PCB (
p
ombe cell
c
ycle
b
ox), which confers M–G
1
‐specific transcription. Sequences similar to the PCB are present in the promoters of seven other genes,
spo12
+
,
cdc19
+
,
fin1
+
,
sid2
+
,
ppb1
+
,
mid1
+
/
dmf1
+
and
plo1
+
, which we find to be transcribed at M–G
1
. A transcription factor complex is identified that binds to the PCB sequence, which we name PBF, for
P
CB‐
b
inding
f
actor. Finally, we show that PBF binding activity and consequent gene transcription are regulated by the Plo1p protein kinase, thus invoking a potential auto‐feedback loop mechanism that regulates mitotic gene transcription and passage through septation and cytokinesis. |
| doi_str_mv | 10.1093/emboj/cdf564 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_131061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EMBJ7594781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4281-a1a94649fb370324f4ee2b71e7110e41edb5c12abcaee1fc2b986350c72d36f03</originalsourceid><addsrcrecordid>eNp9kE1P3DAQhi3UChbKrT_A9zbgsZ04OfTQrmBpxUergqh6sRxnsnjrTSLbC-y_7y5BSBza0xzmeefVPIS8B3YErBLHuKz7xbFt2ryQO2QCsmAZZyp_QyaMF5BJKKs9sh_jgjGWlwp2yR5wCSArPiF28D18oAHnK28SRjrHDmkKpos2uCG5vqMm0XSH9CKbAXVdwnBvPG1WwXXzp0XrYtxyazQx0aVLfXKWWvSe2rX1-I68bY2PePg8D8jN6cn19Cw7v5p9nX4-z6zkJWQGTCULWbW1UExw2UpEXitABcBQAjZ1boGb2hpEaC2vq7IQObOKN6JomTggn8a7w6peYmOx2_zh9RDc0oS17o3Trzedu9Pz_l6DAFbAJv9xzNvQxxiwfYkC01vX-sm1Hl1v8HzEH5zH9X9ZfXLx5ZvKK6nKbU025uKwVYhBL_pV6DZm_tXzzLuY8PGlx4Q_ulBC5fr2cqZn4if__ePXdz0VfwG40KSg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>plo1+ regulates gene transcription at the M-G1 interval during the fission yeast mitotic cell cycle</title><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Anderson, Mark ; Ng, Szu Shien ; Marchesi, Vanessa ; MacIver, Fiona H. ; Stevens, Frances E. ; Riddell, Tracy ; Glover, David M. ; Hagan, Iain M. ; McInerny, Christopher J.</creator><creatorcontrib>Anderson, Mark ; Ng, Szu Shien ; Marchesi, Vanessa ; MacIver, Fiona H. ; Stevens, Frances E. ; Riddell, Tracy ; Glover, David M. ; Hagan, Iain M. ; McInerny, Christopher J.</creatorcontrib><description>The regulation of gene expression plays an important part in cell cycle controls. We describe the molecular machinery that co‐ordinates gene transcription at the M–G
1
interval during the fission yeast mitotic cell cycle. A sequence is identified in the
cdc15
+
promoter that we call a PCB (
p
ombe cell
c
ycle
b
ox), which confers M–G
1
‐specific transcription. Sequences similar to the PCB are present in the promoters of seven other genes,
spo12
+
,
cdc19
+
,
fin1
+
,
sid2
+
,
ppb1
+
,
mid1
+
/
dmf1
+
and
plo1
+
, which we find to be transcribed at M–G
1
. A transcription factor complex is identified that binds to the PCB sequence, which we name PBF, for
P
CB‐
b
inding
f
actor. Finally, we show that PBF binding activity and consequent gene transcription are regulated by the Plo1p protein kinase, thus invoking a potential auto‐feedback loop mechanism that regulates mitotic gene transcription and passage through septation and cytokinesis.</description><identifier>ISSN: 0261-4189</identifier><identifier>ISSN: 1460-2075</identifier><identifier>EISSN: 1460-2075</identifier><identifier>DOI: 10.1093/emboj/cdf564</identifier><identifier>PMID: 12411492</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>cell cycle ; EMBO06 ; EMBO09 ; fission yeast ; plo1 ; transcription</subject><ispartof>The EMBO journal, 2002-11, Vol.21 (21), p.5745-5755</ispartof><rights>European Molecular Biology Organization 2002</rights><rights>Copyright © 2002 European Molecular Biology Organization</rights><rights>Copyright © 2002 European Molecular Biology Organization 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4281-a1a94649fb370324f4ee2b71e7110e41edb5c12abcaee1fc2b986350c72d36f03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC131061/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC131061/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27923,27924,45573,45574,46408,46832,53790,53792</link.rule.ids></links><search><creatorcontrib>Anderson, Mark</creatorcontrib><creatorcontrib>Ng, Szu Shien</creatorcontrib><creatorcontrib>Marchesi, Vanessa</creatorcontrib><creatorcontrib>MacIver, Fiona H.</creatorcontrib><creatorcontrib>Stevens, Frances E.</creatorcontrib><creatorcontrib>Riddell, Tracy</creatorcontrib><creatorcontrib>Glover, David M.</creatorcontrib><creatorcontrib>Hagan, Iain M.</creatorcontrib><creatorcontrib>McInerny, Christopher J.</creatorcontrib><title>plo1+ regulates gene transcription at the M-G1 interval during the fission yeast mitotic cell cycle</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><description>The regulation of gene expression plays an important part in cell cycle controls. We describe the molecular machinery that co‐ordinates gene transcription at the M–G
1
interval during the fission yeast mitotic cell cycle. A sequence is identified in the
cdc15
+
promoter that we call a PCB (
p
ombe cell
c
ycle
b
ox), which confers M–G
1
‐specific transcription. Sequences similar to the PCB are present in the promoters of seven other genes,
spo12
+
,
cdc19
+
,
fin1
+
,
sid2
+
,
ppb1
+
,
mid1
+
/
dmf1
+
and
plo1
+
, which we find to be transcribed at M–G
1
. A transcription factor complex is identified that binds to the PCB sequence, which we name PBF, for
P
CB‐
b
inding
f
actor. Finally, we show that PBF binding activity and consequent gene transcription are regulated by the Plo1p protein kinase, thus invoking a potential auto‐feedback loop mechanism that regulates mitotic gene transcription and passage through septation and cytokinesis.</description><subject>cell cycle</subject><subject>EMBO06</subject><subject>EMBO09</subject><subject>fission yeast</subject><subject>plo1</subject><subject>transcription</subject><issn>0261-4189</issn><issn>1460-2075</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAQhi3UChbKrT_A9zbgsZ04OfTQrmBpxUergqh6sRxnsnjrTSLbC-y_7y5BSBza0xzmeefVPIS8B3YErBLHuKz7xbFt2ryQO2QCsmAZZyp_QyaMF5BJKKs9sh_jgjGWlwp2yR5wCSArPiF28D18oAHnK28SRjrHDmkKpos2uCG5vqMm0XSH9CKbAXVdwnBvPG1WwXXzp0XrYtxyazQx0aVLfXKWWvSe2rX1-I68bY2PePg8D8jN6cn19Cw7v5p9nX4-z6zkJWQGTCULWbW1UExw2UpEXitABcBQAjZ1boGb2hpEaC2vq7IQObOKN6JomTggn8a7w6peYmOx2_zh9RDc0oS17o3Trzedu9Pz_l6DAFbAJv9xzNvQxxiwfYkC01vX-sm1Hl1v8HzEH5zH9X9ZfXLx5ZvKK6nKbU025uKwVYhBL_pV6DZm_tXzzLuY8PGlx4Q_ulBC5fr2cqZn4if__ePXdz0VfwG40KSg</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>Anderson, Mark</creator><creator>Ng, Szu Shien</creator><creator>Marchesi, Vanessa</creator><creator>MacIver, Fiona H.</creator><creator>Stevens, Frances E.</creator><creator>Riddell, Tracy</creator><creator>Glover, David M.</creator><creator>Hagan, Iain M.</creator><creator>McInerny, Christopher J.</creator><general>John Wiley & Sons, Ltd</general><general>Nature Publishing Group UK</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20021101</creationdate><title>plo1+ regulates gene transcription at the M-G1 interval during the fission yeast mitotic cell cycle</title><author>Anderson, Mark ; Ng, Szu Shien ; Marchesi, Vanessa ; MacIver, Fiona H. ; Stevens, Frances E. ; Riddell, Tracy ; Glover, David M. ; Hagan, Iain M. ; McInerny, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4281-a1a94649fb370324f4ee2b71e7110e41edb5c12abcaee1fc2b986350c72d36f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>cell cycle</topic><topic>EMBO06</topic><topic>EMBO09</topic><topic>fission yeast</topic><topic>plo1</topic><topic>transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Mark</creatorcontrib><creatorcontrib>Ng, Szu Shien</creatorcontrib><creatorcontrib>Marchesi, Vanessa</creatorcontrib><creatorcontrib>MacIver, Fiona H.</creatorcontrib><creatorcontrib>Stevens, Frances E.</creatorcontrib><creatorcontrib>Riddell, Tracy</creatorcontrib><creatorcontrib>Glover, David M.</creatorcontrib><creatorcontrib>Hagan, Iain M.</creatorcontrib><creatorcontrib>McInerny, Christopher J.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Mark</au><au>Ng, Szu Shien</au><au>Marchesi, Vanessa</au><au>MacIver, Fiona H.</au><au>Stevens, Frances E.</au><au>Riddell, Tracy</au><au>Glover, David M.</au><au>Hagan, Iain M.</au><au>McInerny, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>plo1+ regulates gene transcription at the M-G1 interval during the fission yeast mitotic cell cycle</atitle><jtitle>The EMBO journal</jtitle><stitle>EMBO J</stitle><date>2002-11-01</date><risdate>2002</risdate><volume>21</volume><issue>21</issue><spage>5745</spage><epage>5755</epage><pages>5745-5755</pages><issn>0261-4189</issn><issn>1460-2075</issn><eissn>1460-2075</eissn><abstract>The regulation of gene expression plays an important part in cell cycle controls. We describe the molecular machinery that co‐ordinates gene transcription at the M–G
1
interval during the fission yeast mitotic cell cycle. A sequence is identified in the
cdc15
+
promoter that we call a PCB (
p
ombe cell
c
ycle
b
ox), which confers M–G
1
‐specific transcription. Sequences similar to the PCB are present in the promoters of seven other genes,
spo12
+
,
cdc19
+
,
fin1
+
,
sid2
+
,
ppb1
+
,
mid1
+
/
dmf1
+
and
plo1
+
, which we find to be transcribed at M–G
1
. A transcription factor complex is identified that binds to the PCB sequence, which we name PBF, for
P
CB‐
b
inding
f
actor. Finally, we show that PBF binding activity and consequent gene transcription are regulated by the Plo1p protein kinase, thus invoking a potential auto‐feedback loop mechanism that regulates mitotic gene transcription and passage through septation and cytokinesis.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12411492</pmid><doi>10.1093/emboj/cdf564</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | cell cycle EMBO06 EMBO09 fission yeast plo1 transcription |
| title | plo1+ regulates gene transcription at the M-G1 interval during the fission yeast mitotic cell cycle |
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