The Role of Calsequestrin, Triadin, and Junctin in Conferring Cardiac Ryanodine Receptor Responsiveness to Luminal Calcium

The level of Ca inside the sarcoplasmic reticulum (SR) is an important determinant of functional activity of the Ca release channel/ryanodine receptor (RyR) in cardiac muscle. However, the molecular basis of RyR regulation by luminal Ca remains largely unknown. In the present study, we investigated...

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Veröffentlicht in:	Biophysical journal 2004-04, Vol.86 (4), p.2121-2128
Hauptverfasser:	Györke, Inna, Hester, Nichole, Jones, Larry R., Györke, Sandor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - physiology Calcium - metabolism Calcium Signaling - physiology Calcium-Binding Proteins - metabolism Calsequestrin - metabolism Carrier Proteins - metabolism Channels, Receptors, and Transporters Dogs Ion Channel Gating - physiology Lipid Bilayers - metabolism Membrane Proteins - metabolism Mixed Function Oxygenases - metabolism Muscle Proteins - metabolism Myocardium - metabolism Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism
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