Surface Functionalized Cationic Lipid-DNA Complexes for Gene Delivery: PEGylated Lamellar Complexes Exhibit Distinct DNA-DNA Interaction Regimes

Cationic lipid-DNA (CL-DNA) complexes are abundantly used in nonviral gene therapy clinical applications. Surface functionality is the next step in developing these complexes as competent, target-specific gene carriers. Poly(ethylene glycol) (PEG) is the natural choice to serve as a protective coat...

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Veröffentlicht in:	Biophysical Journal 2004-02, Vol.86 (2), p.1160-1168
Hauptverfasser:	Martin-Herranz, Ana, Ahmad, Ayesha, Evans, Heather M., Ewert, Kai, Schulze, Uwe, Safinya, Cyrus R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations - chemistry Cells, Cultured Coated Materials, Biocompatible - chemical synthesis COMPLEXES DNA DNA - administration & dosage DNA - chemistry DNA - genetics DNA - ultrastructure Drug Delivery Systems - methods Fibroblasts - drug effects Fibroblasts - metabolism Gene Transfer Techniques GENES Lipids - chemistry Liposomes - chemistry Macromolecular Substances Mice PARTICLE ACCELERATORS Polyethylene Glycols - chemistry STANFORD SYNCHROTRON RADIATION LABORATORY Supramolecular Assemblies Surface Properties SYNCHROTRON RADIATION Transfection - methods
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