Conformational Changes in Alamethicin Associated with Substitution of Its α-Methylalanines with Leucines: A FTIR Spectroscopic Analysis and Correlation with Channel Kinetics

Alamethicin, a 20 residue-long peptaibol remains a favorite high voltage-dependent channel-forming peptide. However, the structural significance of its abundant noncoded residues ( α-methylalanine or Aib) for its ion channel activity remains unknown, although a previous study showed that replacement...

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Veröffentlicht in:	Biophysical journal 2004, Vol.86 (1), p.248-253
Hauptverfasser:	Haris, Parvez I., Molle, Gérard, Duclohier, Hervé
Format:	Artikel
Sprache:	eng
Schlagworte:	Alamethicin - chemistry Amino Acid Substitution Aminoisobutyric Acids - chemistry Channels, Receptors, and Transporters Electric Conductivity Ion Channels - chemistry Leucine - chemistry Lipid Bilayers - chemistry Protein Conformation Protein Structure, Secondary Spectroscopy, Fourier Transform Infrared - methods Structure-Activity Relationship
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