Spontaneous Changes in Mitochondrial Membrane Potential in Single Isolated Brain Mitochondria

In this study we measured ΔΨm in single isolated brain mitochondria using rhodamine 123. Mitochondria were attached to coverslips and superfused with K +-based HEPES-buffer medium supplemented with malate and glutamate. In ∼70% of energized mitochondria we observed large amplitude spontaneous fluctu...

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Veröffentlicht in:	Biophysical journal 2003-11, Vol.85 (5), p.3358-3366
Hauptverfasser:	Vergun, Olga, Votyakova, Tatyana V., Reynolds, Ian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioenergetics Biophysics Brain Cells Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - physiology Fluorescence Male Membrane Potentials - physiology Membranes Microscopy, Fluorescence - methods Mitochondria - physiology Mitochondria - ultrastructure Oxidative Stress - physiology Rats Rats, Sprague-Dawley Rhodamine 123
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