Co-Expression of Lens Fiber Connexins Modifies Hemi-Gap-Junctional Channel Behavior

Lens fiber cells contain two gap junction proteins (Cx56 and Cx45.6 in the chicken). Biochemical studies have suggested that these two proteins can form heteromeric connexons. To investigate the biophysical properties of heteromeric lens connexons, Cx56 was co-expressed with Cx45.6 (or its mouse cou...

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Veröffentlicht in:	Biophysical journal 1999, Vol.76 (1), p.198-206
Hauptverfasser:	Ebihara, L., Xu, X., Oberti, C., Beyer, E.C., Berthoud, V.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biophysical Phenomena Biophysics Calcium - pharmacology Chickens Connexins - chemistry Connexins - genetics Connexins - metabolism Eye Proteins - chemistry Eye Proteins - genetics Eye Proteins - metabolism Female Gap Junctions - chemistry Gap Junctions - drug effects Gap Junctions - metabolism Gene Expression In Vitro Techniques Ion Channel Gating Ion Channels - chemistry Ion Channels - drug effects Ion Channels - metabolism Kinetics Lens, Crystalline - chemistry Lens, Crystalline - metabolism Membrane Potentials Mice Oocytes - metabolism Patch-Clamp Techniques Xenopus laevis
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