Structural Determinants of MscL Gating Studied by Molecular Dynamics Simulations

The mechanosensitive channel of large conductance (MscL) in prokaryotes plays a crucial role in exocytosis as well as in the response to osmotic downshock. The channel can be gated by tension in the membrane bilayer. The determination of functionally important residues in MscL, patch-clamp studies o...

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Veröffentlicht in:	Biophysical journal 2001-05, Vol.80 (5), p.2074-2081
Hauptverfasser:	Gullingsrud, Justin, Kosztin, Dorina, Schulten, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Computer Simulation Crystallography, X-Ray Escherichia coli Proteins Hydrogen Bonding Ion Channels - chemistry Ion Channels - metabolism Lipid Bilayers - chemistry Membranes Models, Molecular Molecular biology Mycobacterium tuberculosis - chemistry Osmosis Patch-Clamp Techniques Phosphatidylcholines - chemistry Pressure Protein Conformation Protein Structure, Secondary Proteins Simulation Temperature Time Factors
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