The Use of pHluorins for Optical Measurements of Presynaptic Activity

Genetically encoded reporters for optical measurements of presynaptic activity hold significant promise for measurements of neurotransmission within intact or semi-intact neuronal networks. We have characterized pH-sensitive green fluorescent protein-based sensors (pHluorins) of synaptic vesicle cyc...

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Veröffentlicht in:	Biophysical journal 2000-10, Vol.79 (4), p.2199-2208
Hauptverfasser:	Sankaranarayanan, Sethuraman, De Angelis, Dino, Rothman, James E., Ryan, Timothy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biophysical Phenomena Biophysics Brain Cellular biology Communication Endocytosis Exocytosis Green Fluorescent Proteins Hippocampus - metabolism Hydrogen-Ion Concentration In Vitro Techniques Luminescent Proteins - metabolism Models, Neurological Neurotransmitters Optics and Photonics Presynaptic Terminals - metabolism Rats Rats, Sprague-Dawley Synaptic Transmission
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