The Role of Proline and Glycine in Determining the Backbone Flexibility of a Channel-Forming Peptide

Alamethicin is a helical 20-amino acid voltage-gated channel-forming peptide, which is known to exhibit segmental flexibility in solution along its backbone near α-methylalanine (MeA)-10 and Gly-11. In an α-helical configuration, MeA at position 10 would normally hydrogen-bond with position 14, but...

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