Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension

The spindle checkpoint monitors microtubule attachment and tension at kinetochores to ensure proper chromosome segregation. Previously, PtK1 cells in hypothermic conditions (23 degrees C) were shown to have a pronounced mitotic delay, despite having normal numbers of kinetochore microtubules. At 23...

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Veröffentlicht in:	Molecular biology of the cell 2002-10, Vol.13 (10), p.3706-3719
Hauptverfasser:	Shannon, Katie B, Canman, Julie C, Salmon, E D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - metabolism Antineoplastic Agents, Phytogenic - metabolism Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cell Cycle - physiology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Chromosomes - metabolism Epitopes - metabolism Fluorescence Recovery After Photobleaching Fluorescent Dyes - metabolism Genes, cdc HeLa Cells Humans Kinetochores - metabolism Mad2 Proteins Microinjections Microtubules - metabolism Protein Kinases - genetics Protein Kinases - metabolism Protein-Serine-Threonine Kinases Recombinant Fusion Proteins - metabolism Repressor Proteins Spindle Apparatus - metabolism Stress, Mechanical Temperature Vinblastine - metabolism
Online-Zugang:	Volltext
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