A neural-specific splicing event generates an active form of the Wiskott-Aldrich syndrome protein

Actin polymerization is required for cellular events such as podosome, lamellipode or filopode formation in migrating cells, and members of the Wiskott–Aldrich syndrome protein (WASP) family have essential roles in regulating actin dynamics at the cell leading edge. However, WASP proteins need first...

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Veröffentlicht in:	EMBO reports 2004-09, Vol.5 (9), p.895-900
Hauptverfasser:	Le Page, Yann, Demay, Florence, Salbert, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Alternative Splicing - physiology Amino acids Animals Cercopithecus aethiops Chickens COS Cells COUP Transcription Factor I COUP-TFI DNA-Binding Proteins - metabolism Exons - physiology Genes, Reporter Mutation Neurons - metabolism paxillin PC12 Cells podosomes Protein Isoforms - genetics Protein Isoforms - metabolism Proteins - genetics Proteins - metabolism Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Scientific Report Transcription Factors - metabolism WASP WH1 Wiskott-Aldrich Syndrome Protein
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