IL-2 Negatively Regulates IL-7 Receptor α Chain Expression in Activated T Lymphocytes
Interleukin (IL)-2 is a type I four-α-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor α chain (IL-7Rα) mRNA...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2002-10, Vol.99 (21), p.13759-13764 |
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| container_issue | 21 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Xue, Hai-Hui Kovanen, Panu E. Pise-Masison, Cynthia A. Berg, Maria Radovich, Michael F. Brady, John N. Leonard, Warren J. |
| description | Interleukin (IL)-2 is a type I four-α-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor α chain (IL-7Rα) mRNA and protein. The fact that IL-7Rα is a component of the receptors for both IL-7 and thymic stromal lymphopoietin (TSLP) suggests that IL-2 can negatively regulate signals by each of these cytokines. Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor γ chain, γc, which suggested a possible competition between these cytokines for a receptor component. Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7Rα expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism. |
| doi_str_mv | 10.1073/pnas.212214999 |
| format | Article |
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We now demonstrate that IL-2 potently decreases expression of IL-7 receptor α chain (IL-7Rα) mRNA and protein. The fact that IL-7Rα is a component of the receptors for both IL-7 and thymic stromal lymphopoietin (TSLP) suggests that IL-2 can negatively regulate signals by each of these cytokines. Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor γ chain, γc, which suggested a possible competition between these cytokines for a receptor component. Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7Rα expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.212214999</identifier><identifier>PMID: 12354940</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; Antibodies ; Biological Sciences ; Cells ; Cytokines ; DNA-Binding Proteins - deficiency ; DNA-Binding Proteins - genetics ; Down regulation ; Gene Expression Regulation - drug effects ; Humans ; Immunology ; Interleukin-2 - pharmacology ; Lymphocyte Activation ; Messenger RNA ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Milk Proteins ; Oligonucleotide Array Sequence Analysis ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphorylation ; Protein-Serine-Threonine Kinases ; Proteins ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-akt ; Receptors ; Receptors, Interleukin-7 - genetics ; Receptors, Interleukin-7 - metabolism ; RNA ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal Transduction ; Splenocytes ; STAT5 Transcription Factor ; T lymphocytes ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Trans-Activators - deficiency ; Trans-Activators - genetics</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (21), p.13759-13764</ispartof><rights>Copyright 1993-2002 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Oct 15, 2002</rights><rights>Copyright © 2002, The National Academy of Sciences 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-9db74a80cb707b3230c423fd2a2a771b94209d25f40931adcd6af416a21abfea3</citedby><cites>FETCH-LOGICAL-c490t-9db74a80cb707b3230c423fd2a2a771b94209d25f40931adcd6af416a21abfea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/99/21.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3073481$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3073481$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12354940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Hai-Hui</creatorcontrib><creatorcontrib>Kovanen, Panu E.</creatorcontrib><creatorcontrib>Pise-Masison, Cynthia A.</creatorcontrib><creatorcontrib>Berg, Maria</creatorcontrib><creatorcontrib>Radovich, Michael F.</creatorcontrib><creatorcontrib>Brady, John N.</creatorcontrib><creatorcontrib>Leonard, Warren J.</creatorcontrib><title>IL-2 Negatively Regulates IL-7 Receptor α Chain Expression in Activated T Lymphocytes</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Interleukin (IL)-2 is a type I four-α-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. 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Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7Rα expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Biological Sciences</subject><subject>Cells</subject><subject>Cytokines</subject><subject>DNA-Binding Proteins - deficiency</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Down regulation</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>Immunology</subject><subject>Interleukin-2 - pharmacology</subject><subject>Lymphocyte Activation</subject><subject>Messenger RNA</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Milk Proteins</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Phosphorylation</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>Receptors</subject><subject>Receptors, Interleukin-7 - genetics</subject><subject>Receptors, Interleukin-7 - metabolism</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction</subject><subject>Splenocytes</subject><subject>STAT5 Transcription Factor</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Trans-Activators - deficiency</subject><subject>Trans-Activators - genetics</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhS1ERUNhywqBxQJ1M-H62hOPFyyqqNBKEUiosLU8Hk8y0WQ82DNV81h9kT4TjpKGnwUr6-p85-hYh5BXDKYMJP_QdyZOkSEyoZR6QiYMFMtmQsFTMgFAmRUCxSl5HuMaAFRewDNyypDnQgmYkB_XiwzpF7c0Q3Pr2i395pZjawYXaVJkOq3rBx_owz2dr0zT0cu7PrgYG9_RdF3Y5Et4RW_oYrvpV95uk_kFOalNG93Lw3tGvn-6vJlfZYuvn6_nF4vMpoZDpqpSClOALSXIkiMHK5DXFRo0UrJSCQRVYV4LUJyZylYzUws2M8hMWTvDz8jHfW4_lhtXWdcNwbS6D83GhK32ptF_K12z0kt_qxkqKSH53x_8wf8cXRz0ponWta3pnB-jlsgKnEmZwHf_gGs_hi79TSOksFzmIkHTPWSDjzG4-liEgd7NpXdz6eNcyfDmz_q_8cM-CXh7AHbGR1mplKEZl_ku4vz_hK7Hth3c3ZDQ13t0HdOiR5anYqJg_BdjmbL0</recordid><startdate>20021015</startdate><enddate>20021015</enddate><creator>Xue, Hai-Hui</creator><creator>Kovanen, Panu E.</creator><creator>Pise-Masison, Cynthia A.</creator><creator>Berg, Maria</creator><creator>Radovich, Michael F.</creator><creator>Brady, John N.</creator><creator>Leonard, Warren J.</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><general>The National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20021015</creationdate><title>IL-2 Negatively Regulates IL-7 Receptor α Chain Expression in Activated T Lymphocytes</title><author>Xue, Hai-Hui ; 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| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Antibodies Biological Sciences Cells Cytokines DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Down regulation Gene Expression Regulation - drug effects Humans Immunology Interleukin-2 - pharmacology Lymphocyte Activation Messenger RNA Mice Mice, Inbred C57BL Mice, Knockout Milk Proteins Oligonucleotide Array Sequence Analysis Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein-Serine-Threonine Kinases Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Receptors Receptors, Interleukin-7 - genetics Receptors, Interleukin-7 - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Splenocytes STAT5 Transcription Factor T lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Trans-Activators - deficiency Trans-Activators - genetics |
| title | IL-2 Negatively Regulates IL-7 Receptor α Chain Expression in Activated T Lymphocytes |
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