The D2 dopamine receptor gene as a determinant of reward deficiency syndrome
The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological...
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| Veröffentlicht in: | Journal of the Royal Society of Medicine 1996-07, Vol.89 (7), p.396-400 |
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| container_title | Journal of the Royal Society of Medicine |
| container_volume | 89 |
| creator | BLUM, K SHERIDAN, P. J WOOD, R. C BRAVERMAN, E. R CHEN, T. J. H CULL, J. G COMINGS, D. E |
| description | The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'. |
| doi_str_mv | 10.1177/014107689608900711 |
| format | Article |
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We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Biological and medical sciences</subject><subject>Compulsive Behavior - genetics</subject><subject>Genetic Linkage</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Receptors, Dopamine D2 - genetics</subject><subject>Risk Factors</subject><subject>Substance-Related Disorders - genetics</subject><subject>Syndrome</subject><subject>Toxicology</subject><issn>0141-0768</issn><issn>1758-1095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtKw0AUhgdRaq2-gCDMwm10LpnbRpB6hYKbug5zOWlTmkmYRKVv7xSL6Opwzvedf_EjdEnJDaVK3RJaUqKkNpJoQ4ii9AhNqRK6oMSIYzTdC8XeOEVnw7AheTeST9BEK1UKbqZosVwDfmA4dL1tmwg4gYd-7BJeQd7sgC0OMELK0MYRd3U2vmwK-Vo3voHod3jYxZC6Fs7RSW23A1wc5gy9Pz0u5y_F4u35dX6_KDacCloEQywVPCgONQsUnAysdI65krHaeUaI4VpL8NJ58NoBlM56ZYnzTkoHfIbufnL7D9dC8BDHZLdVn5rWpl3V2ab6T2KzrlbdZ0WZEVqIHHD1N-D381BL5tcHbgdvt3Wy0TfDr8ZpdnKR38rWdCU</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>BLUM, K</creator><creator>SHERIDAN, P. 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The D2 dopamine receptor gene as a determinant of reward deficiency syndrome</atitle><jtitle>Journal of the Royal Society of Medicine</jtitle><addtitle>J R Soc Med</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>89</volume><issue>7</issue><spage>396</spage><epage>400</epage><pages>396-400</pages><issn>0141-0768</issn><eissn>1758-1095</eissn><abstract>The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.</abstract><cop>London</cop><pub>Royal Society of Medicine</pub><pmid>8774539</pmid><doi>10.1177/014107689608900711</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the Royal Society of Medicine, 1996-07, Vol.89 (7), p.396-400 |
| issn | 0141-0768 1758-1095 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Alcoholism and acute alcohol poisoning Biological and medical sciences Compulsive Behavior - genetics Genetic Linkage Humans Medical sciences Receptors, Dopamine D2 - genetics Risk Factors Substance-Related Disorders - genetics Syndrome Toxicology |
| title | The D2 dopamine receptor gene as a determinant of reward deficiency syndrome |
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