The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

We discovered that the hepatitis C virus (HCV) envelope glycoprotein E2 binds to human hepatoma cell lines independently of the previously proposed HCV receptor CD81. Comparative binding studies using recombinant E2 from the most prevalent 1a and 1b genotypes revealed that E2 recognition by hepatoma...

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Veröffentlicht in:	The EMBO journal 2002-10, Vol.21 (19), p.5017-5025
Hauptverfasser:	Scarselli, Elisa, Ansuini, Helenia, Cerino, Raffaele, Roccasecca, Rosa Maria, Acali, Stefano, Filocamo, Gessica, Traboni, Cinzia, Nicosia, Alfredo, Cortese, Riccardo, Vitelli, Alessandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - physiology Carcinoma, Hepatocellular CD36 Antigens - physiology CHO Cells Cloning, Molecular Cricetinae EMBO19 EMBO23 Flow Cytometry Genotypes Hepacivirus - physiology Hepatitis hepatitis C virus Humans hypervariable region 1 Leukemia, T-Cell Liver Neoplasms Membrane Proteins - physiology Receptors, Immunologic Receptors, Lipoprotein - physiology Receptors, Scavenger Receptors, Virus - physiology Recombinant Proteins - metabolism scavenger receptor class B type I Scavenger Receptors, Class B second envelope glycoprotein Tetraspanin 28 Tumor Cells, Cultured
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