A sensitive denaturing gradient-gel electrophoresis assay reveals a high frequency of heteroplasmy in hypervariable region 1 of the human mtDNA control region

A population study of heteroplasmy in the hypervariable region 1 (HV1) portion of the human mtDNA control region was performed. Blood samples from 253 randomly chosen individuals were examined using a sensitive denaturing gradient-gel electrophoresis (DGGE) system. This method is capable of detectin...

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Veröffentlicht in:	American journal of human genetics 2000-08, Vol.67 (2), p.432-443
Hauptverfasser:	TULLY, L. A, PARSONS, T. J, STEIGHNER, R. J, HOLLAND, M. M, MARINO, M. A, PRENGER, V. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Cytoplasm - genetics DNA Mutational Analysis - methods DNA, Mitochondrial - genetics Electrophoresis, Agar Gel Ethnic Groups - genetics Evolution, Molecular General aspects. Genetic counseling Genetic Variation - genetics Humans Least-Squares Analysis Medical genetics Medical sciences Mitochondria - genetics Mutation - genetics Nucleic Acid Denaturation - genetics Nucleic Acid Heteroduplexes - genetics Phylogeny Polymerase Chain Reaction Regulatory Sequences, Nucleic Acid - genetics Sensitivity and Specificity
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