In vitro selection, characterization, and application of deoxyribozymes that cleave RNA

Over the last decade, many catalytically active DNA molecules (deoxyribozymes; DNA enzymes) have been identified by in vitro selection from random-sequence DNA pools. This article focuses on deoxyribozymes that cleave RNA substrates. The first DNA enzyme was reported in 1994 and cleaves an RNA linka...

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Veröffentlicht in:	Nucleic acids research 2005-01, Vol.33 (19), p.6151-6163
1. Verfasser:	Silverman, Scott K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry - history Biosensing Techniques Catalysis DNA, Catalytic - chemistry DNA, Catalytic - metabolism History, 20th Century RNA - chemistry RNA - metabolism RNA, Messenger - metabolism Survey and Summary
Online-Zugang:	Volltext
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