Effect of repetitive activation on the afterhyperpolarization in dorsal spinocerebellar tract neurones
1. The changes in the afterhyperpolarization (a.h.p.) with repetitive activation have been studied in dorsal spinocerebellar tract cells of the cat using intracellular recording techniques. 2. The a.h.p. following a single spike was conditioned at different interspike intervals by a single preceding...
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| Veröffentlicht in: | The Journal of physiology 1978-02, Vol.275 (1), p.303-319 |
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| creator | Gustafsson, B Zangger, P |
| description | 1. The changes in the afterhyperpolarization (a.h.p.) with repetitive activation have been studied in dorsal spinocerebellar
tract cells of the cat using intracellular recording techniques. 2. The a.h.p. following a single spike was conditioned at
different interspike intervals by a single preceding spike. In the majority of neurones the a.h.p. following a spike added
approximately linearly with that generated by a preceding spike. 3. In other cells the a.h.p. following a spike was instead
depressed by a preceding spike. THis depression was approximately constant at interspike intervals less than the a.h.p. duration
(50-100 msec). Thereafter the a.h.p. slowly recovered during the next 100-300 msec. There was no associated decrease in the
initial brief hyperpolarizing undershoot. 4. With shortlasting repetitive activation at high frequency (greater than 100 impulses/sec)
the a.h.p, peak amplitude increased progressively with successive spikes (5-15 spikes). No change in the time constant of
decay was observed. A good correspondence was found between the observed increase in peak amplitude of the a.h.p.s and that
given by a theoretical linear superposition of the successive a.h.p.s. 5. Changes in the brief hyperpolarizing undershoot
with repetitive activation is also described. |
| doi_str_mv | 10.1113/jphysiol.1978.sp012191 |
| format | Article |
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tract cells of the cat using intracellular recording techniques. 2. The a.h.p. following a single spike was conditioned at
different interspike intervals by a single preceding spike. In the majority of neurones the a.h.p. following a spike added
approximately linearly with that generated by a preceding spike. 3. In other cells the a.h.p. following a spike was instead
depressed by a preceding spike. THis depression was approximately constant at interspike intervals less than the a.h.p. duration
(50-100 msec). Thereafter the a.h.p. slowly recovered during the next 100-300 msec. There was no associated decrease in the
initial brief hyperpolarizing undershoot. 4. With shortlasting repetitive activation at high frequency (greater than 100 impulses/sec)
the a.h.p, peak amplitude increased progressively with successive spikes (5-15 spikes). No change in the time constant of
decay was observed. A good correspondence was found between the observed increase in peak amplitude of the a.h.p.s and that
given by a theoretical linear superposition of the successive a.h.p.s. 5. Changes in the brief hyperpolarizing undershoot
with repetitive activation is also described.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1978.sp012191</identifier><identifier>PMID: 633119</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Action Potentials ; Animals ; Cats ; Cerebellum - physiology ; Electric Conductivity ; Membrane Potentials ; Neurons - physiology ; Spinal Cord - physiology</subject><ispartof>The Journal of physiology, 1978-02, Vol.275 (1), p.303-319</ispartof><rights>1978 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4473-97adf4baa66cecddebac38eb5b9aa346de67c88ab789907ed75def68843215623</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282546/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282546/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/633119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gustafsson, B</creatorcontrib><creatorcontrib>Zangger, P</creatorcontrib><title>Effect of repetitive activation on the afterhyperpolarization in dorsal spinocerebellar tract neurones</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. The changes in the afterhyperpolarization (a.h.p.) with repetitive activation have been studied in dorsal spinocerebellar
tract cells of the cat using intracellular recording techniques. 2. The a.h.p. following a single spike was conditioned at
different interspike intervals by a single preceding spike. In the majority of neurones the a.h.p. following a spike added
approximately linearly with that generated by a preceding spike. 3. In other cells the a.h.p. following a spike was instead
depressed by a preceding spike. THis depression was approximately constant at interspike intervals less than the a.h.p. duration
(50-100 msec). Thereafter the a.h.p. slowly recovered during the next 100-300 msec. There was no associated decrease in the
initial brief hyperpolarizing undershoot. 4. With shortlasting repetitive activation at high frequency (greater than 100 impulses/sec)
the a.h.p, peak amplitude increased progressively with successive spikes (5-15 spikes). No change in the time constant of
decay was observed. A good correspondence was found between the observed increase in peak amplitude of the a.h.p.s and that
given by a theoretical linear superposition of the successive a.h.p.s. 5. Changes in the brief hyperpolarizing undershoot
with repetitive activation is also described.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Cats</subject><subject>Cerebellum - physiology</subject><subject>Electric Conductivity</subject><subject>Membrane Potentials</subject><subject>Neurons - physiology</subject><subject>Spinal Cord - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktr3TAQhUXp6zbtPyjFq6abe6uRbD02gTakLwLtIl0LWR7HCr6WK_kmuL8-Mk5CuykFwcCcbw4zHBHyBugOAPj7q7Gbkw_9DrRUuzRSYKDhEdlAKfRWSs0fkw2ljG25rOA5eZHSFaXAqdbPyFPBOYDekPasbdFNRWiLiCNOfvLXWFiXi518GIr8pi532gljN48Yx9Db6H-vqh-KJsRk-yKNfggOI9bYZ6CYYjYpBjzEMGB6SZ60tk_46q4ekZ-fzi5Ov2zPv3_-evrhfOvKUvKtlrZpy9paIRy6psHaOq6wrmptLS9Fg0I6pWwtldZUYiOrBluhVMkZVILxI3Ky-o6Heo-NwyHv0Zsx-r2NswnWm7-VwXfmMlwbYIpVpcgGb-8MYvh1wDSZvU9uOWnAcEhGcVVpxlQG3_0TBKFLLRmFMqNiRV0MKUVsH_YBapYszX2WZsnS3GeZB1__ec3D2Bpelj-u8o3vcf5PU3Px7cfSYPlTcMqzyfFq0vnL7sZHNOtYCs7jNJvMGTALeQvkTcUk</recordid><startdate>19780201</startdate><enddate>19780201</enddate><creator>Gustafsson, B</creator><creator>Zangger, P</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19780201</creationdate><title>Effect of repetitive activation on the afterhyperpolarization in dorsal spinocerebellar tract neurones</title><author>Gustafsson, B ; Zangger, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4473-97adf4baa66cecddebac38eb5b9aa346de67c88ab789907ed75def68843215623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Cats</topic><topic>Cerebellum - physiology</topic><topic>Electric Conductivity</topic><topic>Membrane Potentials</topic><topic>Neurons - physiology</topic><topic>Spinal Cord - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gustafsson, B</creatorcontrib><creatorcontrib>Zangger, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gustafsson, B</au><au>Zangger, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of repetitive activation on the afterhyperpolarization in dorsal spinocerebellar tract neurones</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1978-02-01</date><risdate>1978</risdate><volume>275</volume><issue>1</issue><spage>303</spage><epage>319</epage><pages>303-319</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. The changes in the afterhyperpolarization (a.h.p.) with repetitive activation have been studied in dorsal spinocerebellar
tract cells of the cat using intracellular recording techniques. 2. The a.h.p. following a single spike was conditioned at
different interspike intervals by a single preceding spike. In the majority of neurones the a.h.p. following a spike added
approximately linearly with that generated by a preceding spike. 3. In other cells the a.h.p. following a spike was instead
depressed by a preceding spike. THis depression was approximately constant at interspike intervals less than the a.h.p. duration
(50-100 msec). Thereafter the a.h.p. slowly recovered during the next 100-300 msec. There was no associated decrease in the
initial brief hyperpolarizing undershoot. 4. With shortlasting repetitive activation at high frequency (greater than 100 impulses/sec)
the a.h.p, peak amplitude increased progressively with successive spikes (5-15 spikes). No change in the time constant of
decay was observed. A good correspondence was found between the observed increase in peak amplitude of the a.h.p.s and that
given by a theoretical linear superposition of the successive a.h.p.s. 5. Changes in the brief hyperpolarizing undershoot
with repetitive activation is also described.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>633119</pmid><doi>10.1113/jphysiol.1978.sp012191</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1978-02, Vol.275 (1), p.303-319 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1282546 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Action Potentials Animals Cats Cerebellum - physiology Electric Conductivity Membrane Potentials Neurons - physiology Spinal Cord - physiology |
| title | Effect of repetitive activation on the afterhyperpolarization in dorsal spinocerebellar tract neurones |
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