Evidence for chaotic behavior in driven ventricles
Toad ventricles were externally driven by periodic pulses while monophasic action potential (MAP) signals were recorded in seven excised and seven in situ ventricles. As the frequency was slowly increased in steps, the stimulated tissue displayed several dynamic characteristics. Hierarchies of perio...
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| Veröffentlicht in: | Biophysical journal 1989-08, Vol.56 (2), p.273-280 |
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| creator | Savino, G.V. Romanelli, L. González, D.L. Piro, O. Valentinuzzi, M.E. |
| description | Toad ventricles were externally driven by periodic pulses while monophasic action potential (MAP) signals were recorded in seven excised and seven in situ ventricles. As the frequency was slowly increased in steps, the stimulated tissue displayed several dynamic characteristics. Hierarchies of periodic behavior, like phase-locking and period-doubling sequences leading to chaos, were observed. Results showed that subharmonic bifurcations (order one and two) and chaotic-like behavior may systematically occur in the MAP signal within a definite frequency interval in the 1:1 phase locking regime. The chaotic, or more cautiously expressed, chaotic-like behavior is characterized by the power spectrum, the autocorrelation function, the Poincaré map, and the reconstructed 2-D phase portrait. It is concluded that (a) bifurcations of order one and two and the characteristic irregular behavior are evidences of local universal chaotic dynamics in cardiac tissue; (b) there are no qualitative differences in the dynamics of the in situ and excised ventricles; and (c) fibrillation seems to be related to chaotic behavior, but whether they are similar or equivalent phenomena still remains to be seen. |
| doi_str_mv | 10.1016/S0006-3495(89)82673-6 |
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As the frequency was slowly increased in steps, the stimulated tissue displayed several dynamic characteristics. Hierarchies of periodic behavior, like phase-locking and period-doubling sequences leading to chaos, were observed. Results showed that subharmonic bifurcations (order one and two) and chaotic-like behavior may systematically occur in the MAP signal within a definite frequency interval in the 1:1 phase locking regime. The chaotic, or more cautiously expressed, chaotic-like behavior is characterized by the power spectrum, the autocorrelation function, the Poincaré map, and the reconstructed 2-D phase portrait. It is concluded that (a) bifurcations of order one and two and the characteristic irregular behavior are evidences of local universal chaotic dynamics in cardiac tissue; (b) there are no qualitative differences in the dynamics of the in situ and excised ventricles; and (c) fibrillation seems to be related to chaotic behavior, but whether they are similar or equivalent phenomena still remains to be seen.</description><identifier>ISSN: 0006-3495</identifier><identifier>EISSN: 1542-0086</identifier><identifier>DOI: 10.1016/S0006-3495(89)82673-6</identifier><identifier>PMID: 2505870</identifier><identifier>CODEN: BIOJAU</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Bufo arenarum ; Electric Stimulation ; Electrocardiography ; Fundamental and applied biological sciences. 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As the frequency was slowly increased in steps, the stimulated tissue displayed several dynamic characteristics. Hierarchies of periodic behavior, like phase-locking and period-doubling sequences leading to chaos, were observed. Results showed that subharmonic bifurcations (order one and two) and chaotic-like behavior may systematically occur in the MAP signal within a definite frequency interval in the 1:1 phase locking regime. The chaotic, or more cautiously expressed, chaotic-like behavior is characterized by the power spectrum, the autocorrelation function, the Poincaré map, and the reconstructed 2-D phase portrait. It is concluded that (a) bifurcations of order one and two and the characteristic irregular behavior are evidences of local universal chaotic dynamics in cardiac tissue; (b) there are no qualitative differences in the dynamics of the in situ and excised ventricles; and (c) fibrillation seems to be related to chaotic behavior, but whether they are similar or equivalent phenomena still remains to be seen.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bufo arenarum</subject><subject>Electric Stimulation</subject><subject>Electrocardiography</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Heart</topic><topic>Heart - physiology</topic><topic>In Vitro Techniques</topic><topic>Time Factors</topic><topic>Ventricular Function</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savino, G.V.</creatorcontrib><creatorcontrib>Romanelli, L.</creatorcontrib><creatorcontrib>González, D.L.</creatorcontrib><creatorcontrib>Piro, O.</creatorcontrib><creatorcontrib>Valentinuzzi, M.E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biophysical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savino, G.V.</au><au>Romanelli, L.</au><au>González, D.L.</au><au>Piro, O.</au><au>Valentinuzzi, M.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for chaotic behavior in driven ventricles</atitle><jtitle>Biophysical journal</jtitle><addtitle>Biophys J</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>56</volume><issue>2</issue><spage>273</spage><epage>280</epage><pages>273-280</pages><issn>0006-3495</issn><eissn>1542-0086</eissn><coden>BIOJAU</coden><abstract>Toad ventricles were externally driven by periodic pulses while monophasic action potential (MAP) signals were recorded in seven excised and seven in situ ventricles. As the frequency was slowly increased in steps, the stimulated tissue displayed several dynamic characteristics. Hierarchies of periodic behavior, like phase-locking and period-doubling sequences leading to chaos, were observed. Results showed that subharmonic bifurcations (order one and two) and chaotic-like behavior may systematically occur in the MAP signal within a definite frequency interval in the 1:1 phase locking regime. The chaotic, or more cautiously expressed, chaotic-like behavior is characterized by the power spectrum, the autocorrelation function, the Poincaré map, and the reconstructed 2-D phase portrait. It is concluded that (a) bifurcations of order one and two and the characteristic irregular behavior are evidences of local universal chaotic dynamics in cardiac tissue; (b) there are no qualitative differences in the dynamics of the in situ and excised ventricles; and (c) fibrillation seems to be related to chaotic behavior, but whether they are similar or equivalent phenomena still remains to be seen.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2505870</pmid><doi>10.1016/S0006-3495(89)82673-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biological and medical sciences Bufo arenarum Electric Stimulation Electrocardiography Fundamental and applied biological sciences. Psychology Heart Heart - physiology In Vitro Techniques Time Factors Ventricular Function Vertebrates: cardiovascular system |
| title | Evidence for chaotic behavior in driven ventricles |
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