Alterations in Central Nervous System Serotonergic and Dopaminergic Synaptic Activity in Adulthood after Prenatal or Neonatal Chlorpyrifos Exposure

Exposure to chlorpyrifos (CPF) alters neuronal development of serotonin (5HT) and dopamine systems, and we recently found long-term alterations in behaviors related to 5HT function. To characterize the synaptic mechanisms underlying these effects, we exposed developing rats to CPF regimens below the...

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Veröffentlicht in:	Environmental health perspectives 2005-08, Vol.113 (8), p.1027-1031
Hauptverfasser:	Aldridge, Justin E., Meyer, Armando, Seidler, Frederic J., Slotkin, Theodore A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Adulthood Animals Animals, Newborn Brain Brain - drug effects Brain - metabolism Chemical hazards Chlorpyrifos - toxicity Cholinergics Dopamine - metabolism Dosage Female Hippocampus Homovanillic Acid - metabolism Insecticides - toxicity Male Midbrain Neurotoxicity Pesticides Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Serotonin - metabolism Synaptic Transmission - drug effects
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