Prevention of thiopental and thiopental/halothane cardiac sensitization to epinephrine in the sheep
The effects of epinephrine (5 microgram/kg of body weight) on ten unanesthetized sheep were experimentally tested: all sheep displayed serious arrhythmias. Sheep anesthetized with thiopental and thiopental/halothane combination displayed cardiac arrhythmias of the order of 10% and 20% respectively....
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| Veröffentlicht in: | Canadian journal of comparative medicine 1977-10, Vol.41 (4), p.389-395 |
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| container_title | Canadian journal of comparative medicine |
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| creator | Rezakhani, A Edjtehadi, M Szabuniewicz, M |
| description | The effects of epinephrine (5 microgram/kg of body weight) on ten unanesthetized sheep were experimentally tested: all sheep displayed serious arrhythmias. Sheep anesthetized with thiopental and thiopental/halothane combination displayed cardiac arrhythmias of the order of 10% and 20% respectively. Challenge injections of epinephrine (5 microgram/kg of body weight) to ten sheep anesthetized with thiopental, and to the same number of animals after 45 minutes of anesthesia with thiopental/halothane, produced serious arrhythmias. However, following preanesthetic treatment with acepromazine maleate (0.5 mg/kg) to 15 sheep, serious arrhythmias were prevented in all of them when they were given arrhythmic doses of epinephrine. |
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Sheep anesthetized with thiopental and thiopental/halothane combination displayed cardiac arrhythmias of the order of 10% and 20% respectively. Challenge injections of epinephrine (5 microgram/kg of body weight) to ten sheep anesthetized with thiopental, and to the same number of animals after 45 minutes of anesthesia with thiopental/halothane, produced serious arrhythmias. However, following preanesthetic treatment with acepromazine maleate (0.5 mg/kg) to 15 sheep, serious arrhythmias were prevented in all of them when they were given arrhythmic doses of epinephrine.</description><identifier>ISSN: 0008-4050</identifier><identifier>PMID: 922556</identifier><language>eng</language><publisher>Canada</publisher><subject>Acepromazine - pharmacology ; Anesthesia - adverse effects ; Animals ; Arrhythmias, Cardiac - chemically induced ; Drug Synergism ; Epinephrine - adverse effects ; Epinephrine - antagonists & inhibitors ; Female ; Halothane ; Heart - drug effects ; Male ; Preanesthetic Medication ; Sheep ; Thiopental</subject><ispartof>Canadian journal of comparative medicine, 1977-10, Vol.41 (4), p.389-395</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277737/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277737/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/922556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezakhani, A</creatorcontrib><creatorcontrib>Edjtehadi, M</creatorcontrib><creatorcontrib>Szabuniewicz, M</creatorcontrib><title>Prevention of thiopental and thiopental/halothane cardiac sensitization to epinephrine in the sheep</title><title>Canadian journal of comparative medicine</title><addtitle>Can J Comp Med</addtitle><description>The effects of epinephrine (5 microgram/kg of body weight) on ten unanesthetized sheep were experimentally tested: all sheep displayed serious arrhythmias. Sheep anesthetized with thiopental and thiopental/halothane combination displayed cardiac arrhythmias of the order of 10% and 20% respectively. Challenge injections of epinephrine (5 microgram/kg of body weight) to ten sheep anesthetized with thiopental, and to the same number of animals after 45 minutes of anesthesia with thiopental/halothane, produced serious arrhythmias. However, following preanesthetic treatment with acepromazine maleate (0.5 mg/kg) to 15 sheep, serious arrhythmias were prevented in all of them when they were given arrhythmic doses of epinephrine.</description><subject>Acepromazine - pharmacology</subject><subject>Anesthesia - adverse effects</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Drug Synergism</subject><subject>Epinephrine - adverse effects</subject><subject>Epinephrine - antagonists & inhibitors</subject><subject>Female</subject><subject>Halothane</subject><subject>Heart - drug effects</subject><subject>Male</subject><subject>Preanesthetic Medication</subject><subject>Sheep</subject><subject>Thiopental</subject><issn>0008-4050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtKBDEQRbPwPfoHLvIDjZWkO5neCDL4ggFd6LrJo9pEepKQbgf0620ckXFTl1vFPVzqgJwCwLKqoYETcjaO7wC1kK08Jkct500jT4l9LrjFOIUUaerp5EPKs9UD1dHt2SuvhzR5HZFaXVzQlo4YxzCFL_0TnhLFHCJmX-ZJw7zxSEePmM_JYa-HES9-dUFe725fVg_V-un-cXWzrjKXMFWGGWVaqRQKYxwyQObatu6dY7wXyJbARaNB2EZy10sFCqwAaQSTqua1EwtyvePmD7NBZ-fiRQ9dLmGjy2eXdOj-X2Lw3VvadowrpYSaAZf7gL_k7lniGyAvaD0</recordid><startdate>19771001</startdate><enddate>19771001</enddate><creator>Rezakhani, A</creator><creator>Edjtehadi, M</creator><creator>Szabuniewicz, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>19771001</creationdate><title>Prevention of thiopental and thiopental/halothane cardiac sensitization to epinephrine in the sheep</title><author>Rezakhani, A ; Edjtehadi, M ; Szabuniewicz, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p260t-b1b7b9677e3bbde10e1d994fdd12f3e180235a03c562df67070c306b3167424d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Acepromazine - pharmacology</topic><topic>Anesthesia - adverse effects</topic><topic>Animals</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Drug Synergism</topic><topic>Epinephrine - adverse effects</topic><topic>Epinephrine - antagonists & inhibitors</topic><topic>Female</topic><topic>Halothane</topic><topic>Heart - drug effects</topic><topic>Male</topic><topic>Preanesthetic Medication</topic><topic>Sheep</topic><topic>Thiopental</topic><toplevel>online_resources</toplevel><creatorcontrib>Rezakhani, A</creatorcontrib><creatorcontrib>Edjtehadi, M</creatorcontrib><creatorcontrib>Szabuniewicz, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian journal of comparative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezakhani, A</au><au>Edjtehadi, M</au><au>Szabuniewicz, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of thiopental and thiopental/halothane cardiac sensitization to epinephrine in the sheep</atitle><jtitle>Canadian journal of comparative medicine</jtitle><addtitle>Can J Comp Med</addtitle><date>1977-10-01</date><risdate>1977</risdate><volume>41</volume><issue>4</issue><spage>389</spage><epage>395</epage><pages>389-395</pages><issn>0008-4050</issn><abstract>The effects of epinephrine (5 microgram/kg of body weight) on ten unanesthetized sheep were experimentally tested: all sheep displayed serious arrhythmias. Sheep anesthetized with thiopental and thiopental/halothane combination displayed cardiac arrhythmias of the order of 10% and 20% respectively. Challenge injections of epinephrine (5 microgram/kg of body weight) to ten sheep anesthetized with thiopental, and to the same number of animals after 45 minutes of anesthesia with thiopental/halothane, produced serious arrhythmias. However, following preanesthetic treatment with acepromazine maleate (0.5 mg/kg) to 15 sheep, serious arrhythmias were prevented in all of them when they were given arrhythmic doses of epinephrine.</abstract><cop>Canada</cop><pmid>922556</pmid><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0008-4050 |
| ispartof | Canadian journal of comparative medicine, 1977-10, Vol.41 (4), p.389-395 |
| issn | 0008-4050 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1277737 |
| source | MEDLINE; PubMed Central |
| subjects | Acepromazine - pharmacology Anesthesia - adverse effects Animals Arrhythmias, Cardiac - chemically induced Drug Synergism Epinephrine - adverse effects Epinephrine - antagonists & inhibitors Female Halothane Heart - drug effects Male Preanesthetic Medication Sheep Thiopental |
| title | Prevention of thiopental and thiopental/halothane cardiac sensitization to epinephrine in the sheep |
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